芪苈强心胶囊治疗老年收缩性心力衰竭的临床疗效观察  

Observation of clinical effect of Qiliqiangxin capsule on elderly patients with systolic heart failure

作　　者：李争[1,2] 钱玉红[1] 周静[1,2] 王敏[1] 范志媛 张淋淋[1] 梁凤兰[1] 史俊玲[1] 

机构地区：[1]河北联合大学附属唐山市中医医院心内科,063000 [2]天津医科大学研究生院,2013级博士研究生300070

出　　处：《疑难病杂志》2015年第9期895-897,909,共4页Chinese Journal of Difficult and Complicated Cases

基　　金：河北省唐山市科技计划项目(No.13130282b)

摘　　要：目的观察芪苈强心胶囊治疗老年收缩性心力衰竭的临床疗效。方法选取年龄≥65岁的老年收缩性心力衰竭患者196例,随机分为观察组116例和对照组80例。对照组给予常规服用利尿剂、血管紧张素转换酶抑制剂(ACEI)或血管紧张素Ⅱ受体阻滞剂(ARB)、β-受体阻滞剂、洋地黄制剂、硝酸酯类等药物治疗。观察组在对照组治疗基础上给予芪苈强心胶囊口服,于入组时及治疗后8周检测肝功能、肾功能、心肌酶、临床疗效、6分钟步行试验(6 MWT)、左室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、血清N末端脑钠肽前体(NT-proBNP)的变化。结果观察组总有效率优于常规治疗组(92.2%vs.83.85,x^2=6.852,P<0.05);2组LVEF、NT-proBNP均较治疗前好转(t_对=4.431、51.213,t_观=6.132、71.663,P均<0.05),观察组NT-proBNP水平较对照组降低明显(P<0.05);2组肝功能、肾功能、心肌酶治疗前后变化差异均无统计学意义(P>0.05)。结论芪苈强心胶囊有效改善老年收缩性心力衰竭患者的临床症状和心功能,无用药不良反应发生,值得临床推广应用。Objective To observe the therapeutic effect of Qiliqiangxin capsule in the treatment of senile congestive heart failure .Methods Selected 196 cases of age more than or equal 65 elderly patients with systolic heart failure , they were randomly divided to observation group （116 cases） and control group （80 cases）.Control group was given conventional diu-retics, angiotensin angiotensin converting enzyme inhibitor （ACEI） or vascular angiotensin II receptor blocker （ARB）, and beta blockers, digitalis and nitric acid ester drug treatment .The observation group also added Qiliqiangxin capsule treatment, at the beginning and after 8 weeks treatment , liver function , renal function , myocardial enzyme , clinical curative effect , 6 mi-nutes walking test （6MWT）, left ventricular shoot ejection fraction （LVEF）, left ventricular diastolic end diastolic diameter （LVEDD）, serum N-terminal pro brain natriuretic peptide precursor （NT-proBNP） changes were detected.Results Obser-vation group’s total efficiency was superior to the conventional treatment group （92.2%vs.83.85,χ2 =6.852, P 〈0.05）;2 groups’ LVEF, NT-proBNP were improved than before treatment （ t =4.431, t =51.213, t =6.132, t =71.663, P 〈0.05）, observation group’s NT-proBNP levels were decreased more significantly than control group （ P 〈0.05）.The hepatic function , renal function , myocardial enzymes in two groups before and after the treatment ’ s difference had no statistical signif-icance （ P ＆gt;0.05）.Conclusion Qiliqiangxin capsule effectively improves the clinical symptoms and heart function in eld-erly patients with systolic heart failure , no drug adverse events , worthy of clinical application .

关 键 词：芪苈强心胶囊 收缩性心力衰竭 脑钠肽 老年 

分 类 号：R541.6[医药卫生—心血管疾病]