Fractalkine在慢性阻塞性肺疾病急性加重期血清中动态变化及意义  

Dynamic changes and significance of serum fractalkine in patients with acute exacerbation of chronic obstructive lung disease

作　　者：向永红[1] 张云[1] 农智新[1] 梁世锋[1] 戴诗敏[1] 张润娟[1] 廖立新[1] 谢少娟[1] 庞宗东 

机构地区：[1]广西医科大学附属民族医院呼吸科,南宁530001

出　　处：《中华肺部疾病杂志（电子版）》2015年第4期9-12,共4页Chinese Journal of Lung Diseases(Electronic Edition)

基　　金：广西自然科学基金项目(2012GXNSFAA053173);广西卫生厅科研基金(Z2011412)

摘　　要：目的探讨不规则趋化因子(FKN)在慢性阻塞性肺疾病急性加重期(AECOPD)患者血清中的动态变化,以及与白介素-6(IL-6)、高敏C反应蛋白(hs CRP)、第一秒用力呼气容积(FEV1)、COPD评估测试(CAT)评分的相关性。方法 AECOPD的住院患者按病情严重程度及CAT评分分值随机分为普通组和重症组,每组各20例,两组分别按治疗后第10天病情再分为普通缓解组(17例)、普通未缓解组(3例)、重症缓解组(14例)、重症未缓解组(6例),另选20例志愿者为正常对照组,抽取正常对照组及AECOPD患者住院次日、治疗后第10天清早空腹静脉血,测定血清hs CRP、IL-6和FKN的水平,并检查肺功能、CAT评分。结果血清FKN及hs CRP、IL-6在两组AECOPD患者较正常对照组升高(P<0.05),两组缓解组患者治疗后较治疗前明显降低(P<0.05),在两组未缓解组治疗前后无明显差异(P>0.05),重症组较普通组治疗前高(P<0.05);FEV1在普通缓解组治疗前后差异有统计学意义(P<0.05);比较CAT评分在普通组与重症组,以及两组的缓解组患者治疗前后有显著差异(P>0.05);血清FKN与CAT评分及hs CRP、IL-6水平呈正相关(r=0.397、0.421、0.459,P<0.05),与FEV1无明显相关性(r=0.224,P>0.05)。结论 FKN在AECOPD患者血清中呈动态变化,提示FKN参与COPD的发生发展,与hs CRP、IL-6一样可作为一项监测COPD急性发作和病情发展的炎性指标。Objective To investigate the clinical significance of fractalkine in patients with acute exacerbation of chronic obstructive pulmonary disease（ AECOPD） by means of observation the dynamic changes of serum fractalkine,and the relativity of fractalkine with interleukin-6（ IL-6）,high-sensitivity C-reactive protein（ hs CRP）,FEV1,COPD assessment test（ CAT）. Methods A total of forty inpatients with AECOPD were divided into two groups in accordance with order of severity and score of CAT： Common groups and serious groups,Two groups were divided into four groups in accordance with state of an illness at the 10 th day of posttreatment： common remission groups（ 17 cases）,common non-remission groups（ 3 cases）, servious remission groups（ 14 cases）,servious non-remission groups（ 16 cases）. Twenty healthy volunteer were selected as normal control. To measure the serum leves of fractalkine,IL-6 and CRP,and examine pulmonary function and CAT at twomrrow in hospital or the 10 th day of posttreatment in patients with AECOPD. Results The serum leves of fractalkine and CRP were increased in two AECOPD groups comparison with normal control（ P〈0. 05）,and were obviously decreased posttreatment comparison with prior treatment in two remission（ P〈0. 05）. and were increased comparison with posttreatment in servious groups and common groups（ P〈0. 05）.All data were not different between post and prior treatment in two non-remission groups（ P〉0. 05）. FEV1 were statistically significant by comparison with post and prior treatment in common remission groups（ P〈0. 05）; CAT were statistically significant by comparison with servious groups and common group s（ P〈0. 05）,post and prior treatment in two remission groups; Fractalkine showed positive correlation with CAT,hs CRP and IL-6（ r = 0. 397,0. 421,0. 459,P〈0. 05）,and uncorrelation with FEV1（ r = 0. 224,P〉0. 05）. Conclusion The dynamic changes of serum fractalkine in Patients with AECOPD prompt that fractalkine p

关 键 词：肺疾病 慢性阻塞性 趋化因子 C反应蛋白 

分 类 号：R563[医药卫生—呼吸系统]