辛伐他汀治疗急性心肌梗死的临床疗效及其对白介素17、超敏C反应蛋白的影响研究  

Clinical Effect of Simvastatin on Acute Myocardial Infarction and Its Impact on IL-17 and hs-CRP

作　　者：张超锋 王二伟 

机构地区：[1]西电集团医院心血管内科,陕西省西安市710077

出　　处：《实用心脑肺血管病杂志》2015年第7期26-29,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的观察辛伐他汀治疗急性心肌梗死的临床疗效及其对白介素17(IL-17)、超敏C反应蛋白(hs-CRP)的影响。方法选取2012年2月—2014年8月西安市西电集团医院收治的69例急性心肌梗死患者,根据入院时间顺序分成观察组35例和对照组34例。对照组患者给予常规治疗,观察组在对照组基础上采用辛伐他汀治疗,两组患者均治疗15 d。比较两组患者临床疗效、心血管不良事件发生情况,治疗前后血清IL-17水平、血浆hs-CRP水平及血脂指标〔总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)和高密度脂蛋白(HDL)〕。结果观察组患者临床疗效优于对照组,差异有统计学意义(u=3.090,P=0.002)。治疗前两组患者血浆hs-CRP水平、血清IL-17水平比较,差异无统计学意义(P>0.05);治疗后观察组患者血浆hs-CRP水平、血清IL-17水平均低于对照组(P<0.05)。治疗前两组患者TC、TG、LDL及HDL水平比较,差异无统计学意义(P>0.05);治疗后观察组患者TC、TG、LDL水平低于对照组,HDL水平高于对照组(P<0.05)。两组患者再次心肌梗死发生率和病死率比较,差异无统计学意义(P>0.05);观察组患者心律失常发生率低于对照组(P<0.05)。结论辛伐他汀治疗急性心肌梗死患者的临床疗效确切,能有效降低血清IL-17、血浆hs-CRP水平,改善血脂,有助于减少心血管不良事件的发生。Objective To observe the clinical effect of simvastatin on acute myocardial infarction and its impact on IL-17 and hs-CRP. Methods A total of 69 patients with acute myocardial infarction were selected in the Hospital of China XD Group from February 2012 to August 2014,and they were divided into control group（ n = 34） and observation group（ n = 35）according to admission time. Patients of control group were given conventional treatment,while patients of observation group were given extra simvastatin based on conventional treatment,both groups treated for 15 days. Clinical effect, incidence of adverse cardiovascular events, serum IL-17 level, plasma hs-CRP level and blood lipid parameters（ including TC, TG, LDL,HDL） before and after treatment were compared between the two groups. Results The clinical effect of observation group was statistically significantly better than that of control group（ u = 3. 090, P = 0. 002）. No statistically significant differences of serum IL-17 level,plasma hs-CRP level,TC,TG,LDL or HDL was found between the two groups before treatment（ P〈0. 05）; after treatment,serum IL-17 level,plasma hs-CRP level,TC,TG and LDL of observation group were statistically significantly lower than those of control group,while HDL of observation group was statistically significantly higher than that of control group（ P〈0. 05）. No statistically significant differences of incidence of re-infarction or fatality rate was found between the two groups,while incidence of arrhythmia of observation group was statistically significantly lower than that of control group（ P〈0. 05）. Conclusion Simvastatin is certainly effective in treating acute myocardial infarction,which can effectively reduce the serum IL-17 level and plasma hs-CRP level, improve the blood lipid, is helpful to reduce the incidence of adverse cardiovascular events.

关 键 词：心肌梗死 辛伐他汀 白细胞介素类 C反应蛋白质 

分 类 号：R542.22[医药卫生—心血管疾病]