红细胞分布宽度对重叠综合征的预测价值研究  

Predictive Value of Red Cell Distribution Width in Patients with COPD-OSAHS Overlap Syndrome

作　　者：史菲[1] 张婷[2] 刘雯雯[2] 

机构地区：[1]暨南大学第二临床医学院急诊科,广东省深圳市518020 [2]暨南大学第二临床医学院呼吸科,广东省深圳市518020

出　　处：《实用心脑肺血管病杂志》2015年第7期33-35,39,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：国家自然科学基金(81300012)

摘　　要：目的探讨红细胞分布宽度(RDW)对重叠综合征的预测价值。方法连续收集2013年6月—2015年1月在暨南大学第二临床医学院住院治疗的20例轻度COPD患者(A组)、20例中重度COPD患者(B组)、20例轻度重叠综合征患者(C组)及20例中重度重叠综合征患者(D组),并根据RDW参考范围将所有患者分为RDW正常组59例和RDW增高组21例。比较A、B、C、D 4组患者一般资料、动脉血气分析指标〔p H值、动脉血氧分压(Pa O2)、动脉血二氧化碳分压(Pa CO2)〕、血浆超敏C反应蛋白(hs-CRP)水平及RDW;比较RDW正常组与RDW增高组患者一般资料、动脉血气分析指标及血浆hs-CRP水平;并分析RDW与Pa O2、血浆hs-CRP水平的相关性。结果 4组患者性别、年龄及p H值比较,差异无统计学意义(P>0.05);A组和B组患者Pa O2高于D组,血浆hsCRP水平和RDW低于D组,C组患者Pa CO2低于D组,A组和B组患者RDW低于C组(P<0.05)。RDW正常组与RDW增高组患者性别、年龄、p H值及Pa CO2比较,差异无统计学意义(P>0.05);RDW增高组患者血浆hs-CRP水平高于RDW正常组、Pa O2低于RDW正常组(P<0.05)。Pearson相关分析结果显示,RDW与Pa O2呈负相关(r=-0.265,P=0.018),与血浆hs-CRP水平呈正相关(r=0.258,P=0.021)。结论 RDW可用于重叠综合征患者炎症及气道病变严重程度的初步评估,具有一定的预测价值。Objective To investigate the predictive value of red cell distribution width（ RDW） in patients with COPD-OSAHS overlap syndrome. Methods From June 2013 to January 2015 in the Second Clinical College of Ji＇ nan University,20 inpatients with mild COPD were selected as A group,20 inpatients with moderate and severe COPD were selected as B group,20 inpatients with mild COPD-OSAHS overlap syndrome were selected as C group,20 inpatients with moderate and severe COPD-OSAHS were selected as D group,and they were also divided into E group（ with normal RDW,n = 59） and F group（ with increased RDW, n = 21） according to RDW reference range. General information, arterial blood-gas analysis index（ including p H,Pa O2,Pa CO2）,plasma hs-CRP level and RDW were compared among the four groups（ A,B,C and D）; general information,arterial blood-gas analysis index（ including p H,Pa O2,Pa CO2） and plasma hs-CRP level were compared between the two groups（ E and F）; correlations between RDW and Pa O2,plasma hs-CRP level was respectively analyzed. Results No statistically significant differences of gender,age or p H was found among the four groups（ P〈0. 05）;Pa O2 of A group and B group was statistically significantly higher than that of D group,respectively,plasma hs-CRP level of A group and B group was statistically significantly lower than that of D group,respectively,Pa CO2 of C group was statistically significantly lower than that of D group,RDW of A group and B group was statistically significantly higher than that of C group,respectively（ P〈0. 05）. No statistically significant differences of gender,age,p H or Pa CO2 was found between the two groups（ P〈0. 05）; plasma hs-CRP level of F group was statistically significantly higher than that of E group,while Pa O2 of F group was statistically significantly lower than that of E group（ P〈0. 05）. Pearson correlation analysis showed that, RDW was negatively correlated with Pa O2（ r =-0. 265,P = 0. 018）,was positively correlated with pl

关 键 词：肺疾病 慢性阻塞性 睡眠呼吸暂停 阻塞性 红细胞分布宽度 预测 

分 类 号：R563[医药卫生—呼吸系统] R563.8[医药卫生—内科学]