综合性预防措施对低龄儿童呼吸道疾病应用阿奇霉素治疗的不良反应事件的影响  

Effect of the Comprehensive Preventive Measures on Adverse Reaction of Azithromycin Treating Young Children with Respiratory Disease

作　　者：张明娣[1] 胡艳红[2] 王智[1] 

机构地区：[1]东风汽车公司花果医院药剂科,湖北十堰442049 [2]东风汽车公司总医院药剂科,湖北十堰442049

出　　处：《医学综述》2015年第17期3262-3263,共2页Medical Recapitulate

摘　　要：目的分析低龄儿童（6岁以下）呼吸道疾病应用阿奇霉素的不良反应事件并探讨合理的预防措施。方法选择2013年1-12月在十堰市东风汽车公司花果医院使用阿奇霉素治疗的低龄儿童作为研究对象。在2013年7月后实施综合性的预防措施。随机抽取2013年1-6月的300例病例资料作为对照组。另选2013年7～12月病例300例作为观察组。比较两组患儿各类不良反应发生率。结果预防措施实施后，观察组消化系统[21．O％（63／300）比28．7％（86／300）]、泌尿系统[5．3％（16／300）比10．0％（30／300）]、循环系统[3．7％（11／300）比7．7％（23／300）]、过敏性休克[2．0％（6／300）比5．O％（15／300）]不良反应发生率较对照组均明显降低（P〈0．05）。观察组不良反应发生率与对照组比较明显降低（P〈0．01）。结论通过采取预防措施可有效降低阿奇霉素所致不良反应的发生率。Objective To analyze the adverse reaction of young children with respiratory disease caused by asithromyein, and explore the reasonable precautions. Methods Young children treated by asithromyein in Shiyan Huaguo Hospital of Dongfeng Motor Corporation from Jan. to Dec. 2013 were included in the study. The general precautions was implemented after July 2013,300 eases from Jan. to Jun. 2013 were included as control group,300 eases from Jul. to Dec; 2013 were included as the observation group. The type of adverse reaction and the incidence of adverse reactions were selected as evaluating indicators. Results After the implementation of preventive measures, the incidence of adverse reactions of the digestive system [ 21.0% （63/300） vs 28.7% （86/300） ] ,the urinary system [5.3% （16/300） vs 10.0% （30/300） ] ,the circu- latory system [ 3.7 % （11/300） vs 7.7 % （23/300） ] were significantly lower than before the implementa- tion of preventive measures （ P 〈 0.05 ）. After the implementation of preventive measures, the incidence of adverse reactions in the observation group was significantly lower than the control group （ P 〈 0.01 ）. Conclusion The comprehensive preventive measures can effectively reduce the incidence of azithremyein- induced adverse reactions.

关 键 词：呼吸道疾病 阿奇霉素 低龄儿童 不良反应 预防措施 

分 类 号：R942[医药卫生—药剂学]