右美托咪定对全麻苏醒期拔管反应的影响  

Effects of dexmedetomidine on patients after general anesthesia during endotracheal extubation

作　　者：张槐根[1] 喻剑萍[1] 余桂媛[1] 胡真真[1] 雷恩骏[1] 

机构地区：[1]南昌大学第一附属医院麻醉科,南昌330006

出　　处：《江西医药》2015年第8期734-735,共2页Jiangxi Medical Journal

基　　金：江西省卫生厅资助课题(20143039)

摘　　要：目的探讨右美托咪定减轻全麻苏醒期拔管反应的临床效果。方法气管内插管全麻术后入麻醉恢复室(PACU)的病人200例随机分为2组,右美托咪定组(A组)和对照组(B组),各100例。A组入PACU时即给予右美托咪定0.5μg/kg,10min泵注完毕;B组给予同等剂量的生理盐水。记录入PACU时基础值(T0)、拔管时(T1)、拔管后5min(T2)、拔管后30min(T3)不同时间点患者的血压、心率、脉氧饱和度,记录苏醒时间、拔管时间。结果 A组T1、T2时间点血压和心率与B组相比降低(P<0.05),A组苏醒时间、拔管时间与B组相比无统计学差异(P<0.05)。结论右美托咪定可以减轻全麻苏醒期拔管反应。Objective To observe the clinic effects of dexmedetomidine on patients after general anesthesia during endotracheal extubation. Methods 200 patients with endotracheal intubation in post-anesthesia-care-unit（PACU） were randomly divided into two groups. At the time to PACU,dexmedetomidine at a dose of 0.5μg/kg in Group A（Ddexmedetomidine Group,n=100） and saline in Group B（control Group n =100） were administrated intravenously in 10 mins. BP,HR,Sp O2 were recorded at different time：time to PACU（T0）,time to extubation（T1）,5mins after extubation（T2）,30 mins after extubation（T3）. The time of palinesthesia and extubation were recorded too. Results The BP and HR of Group A were lower than Group B at time T1、T2（P〈0.05）. There was no difference on the time of palinesthesia and extubation between two groups（P〈0.05）. Conclusion Dexmedetomidine used in PACU could depress extubation reaction.

关 键 词：右美托咪定 全麻苏醒 麻醉恢复室 

分 类 号：R614[医药卫生—麻醉学]