来曲唑个体化治疗对克罗米芬抵抗多囊卵巢综合征疗效分析  

Analysis of individualized letrozole therapy for polycystic ovary syndrome patients resistant to clomiphene

作　　者：柳顺玉[1] 阮祥燕[1] 刘玉兰[1] 

机构地区：[1]首都医科大学附属北京妇产医院内分泌科,北京100026

出　　处：《徐州医学院学报》2015年第7期468-470,共3页Acta Academiae Medicinae Xuzhou

基　　金：北京市卫生系统高层次卫生技术人才培养计划项目（2009-3-52）;首都医科大学附属北京妇产医院,北京妇幼保健院学科带头人项目（2013-1）

摘　　要：目的探讨来曲唑个体化促排卵治疗对克罗米芬抵抗多囊卵巢综合征（PCOS）不孕患者的疗效。方法52例克罗米芬抵抗PCOS不孕确诊患者，严密监测卵泡发育下，给予来曲唑个体化延长治疗，观察来曲唑每周期用药量、优势卵泡数、人绒毛膜促性腺激素（hCG）注射日及子宫内膜厚度、排卵率和妊娠率，分析临床疗效。结果52例患者来曲唑个体化延长促排卵治疗共102个周期，来曲唑平均周期用药量（42．73±13．73）mg[（17．09±5．49）片]；排卵率91．17％，妊娠率为65．38％；无卵巢过度刺激综合征发生。结论对克罗米芬抵抗PCOS不孕患者，在严密监测下，来曲唑个体化延长治疗可以取得安全有效的促排卵和妊娠结果。Objective To investigate the clinical efficacy of individualized letrozole therapy for polycystic ovary syn- drome （PCOS） patients resistant to clomiphene. Methods A total of 52 PCOS patients resistant to clomiphene were en- rolled in the current study. They were administrated with individualized letrozole therapy, while their follicle growth was strictly monitored. Then, the following information was recorded to analyze clinical efficacy： the weekly dosage of letro- zole, the number of dominant follicles, hCG injection date, endometrial thickness, and the rates of ovulation and preg- nancy. Results The individualized letrozole therapy was applied for 102 cycles. The average dosage of letrozole was （42.73 ±13.73） mg [ （ 17.09 ± 5.49） tablets]. The rates of ovulation and pregnancy were 91. 17% and 65.38%, respectively. No ovarian hyperstimulation syndrome was reported. Conclusion Individualized letrozole therapy can ef- fectively improve the rates of ovulation and pregnancy for PCOS patients resistant to clomiphene under strictly monitoring conditions.

关 键 词：多囊卵巢综合征 不孕 克罗米芬抵抗 来曲唑 个体化治疗 

分 类 号：R711.75[医药卫生—妇产科学]