系统性红斑狼疮动物模型研究进展  

Research progress of animal models of systemic lupus erythematosus

作　　者：阎雨[1] 方莲花[1] 杜冠华[1] 

机构地区：[1]中国医学科学院.北京协和医学院药物研究所药物靶点研究和新药筛选北京市重点实验室,北京100050

出　　处：《中国实验动物学报》2015年第4期428-433,共6页Acta Laboratorium Animalis Scientia Sinica

基　　金："重大新药创制"科技重大专项(2013ZX09103-001-008;2012ZX09103-101-078;2013ZX09508104)

摘　　要：系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种慢性多系统复发性自身免疫性疾病,严重危害人类健康。狼疮动物模型对于研究SLE的病因、发病机制和治疗具有重要意义。本文对各种狼疮动物模型进行评述和比较,以期探讨各种模型的优缺点,为研究者在寻找特定的致病机制、开发针对性的干预措施以及更具潜力的治疗药物过程中选择合适的模型提供参考。Systemic lupus erythematosus（ SLE） is a chronic multisystem relapsing-remitting autoimmune disease,which affects human health seriously. There are numerous animal models that have long been employed in an effort to understand the mechanism and treatment of SLE. Animal models of SLE were reviewed and compared in this paper,to provide references for the researchers to choose appropriate models for studying specific pathogenic mechanism and diagnostic criteria,searching for targeted treatment interventions and developing potential therapeutic drugs.

关 键 词：系统性红斑狼疮 小鼠 动物模型 

分 类 号：Q95-33[生物学—动物学]