系统性红斑狼疮患者亚临床甲状腺功能减退症发病的影响因素研究  

Influencing factor of attacking sub clinical hypothyroidism for patients with systemic lupus erythematosus

作　　者：鲍晓[1] 黄向阳[2] 

机构地区：[1]德阳市人民医院风湿免疫科,四川德阳618000 [2]四川大学华西医院风湿免疫科,四川成都610041

出　　处：《西部医学》2015年第9期1315-1317,共3页Medical Journal of West China

基　　金：国家自然科学基金(81072477)

摘　　要：目的 探讨系统性红斑狼疮（SLE）患者亚临床甲状腺功能减退症（SCH）发病的影响因素.方法 选取2009年4月～2014年12月收治的SLE合并SCH患者140例作为观察组,选取同期入院的单纯SLE患者140例作为对照组.统计患者相关资料,所有患者均行常规腹部超声检查（肝、胆、胰、脾、肾）,血液检查包括空腹血糖（FBG）、血脂[三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）]、血肌酐（SCr）、尿素氮（BUN）、超敏C反应蛋白（hs-CRP）,24 h尿蛋白和血清白蛋白.结果 观察组患者关节病变和有雷诺现象的比例显著高于对照组（P＜0.01）,其余指标两组间差异无显著性（均P＞0.05）.观察组和对照组在TC、TG、SCr、24h尿蛋白定量和血清白蛋白水平差异均有显著性（均P＜0.05）,其他指标两组间差异无显著性（P＞0.05）.Logistic回归分析显示,TC、TG、SCr、24h尿蛋白量和血清白蛋白水平为SLE患者SCH发病的独立危险因素（P＜0.01）.结论 TC、TG、SCr、24h尿蛋白量和血清白蛋白水平为SLE患者SCH发病的独立危险因素,应密切监测以上指标,为防止SCH的发生提供处治依据.Objective To investigate the influencing factor of attacking sub clinical hypothyroidism （SCH） for patients with systemic lupus erythematosus （SLE）. Method 140 patients with SLE and SCH in our hospital from Apt 2009 to Dec 2014 were used as observation group and another 140 cases of patients with only SLE were used as control group. General clinical data was collected and blood inspecting including fast blood glucose, blood lipid [triacylglyeerol （TG）, total cholesterol （TC）, high-density lipoprotein （HDL）, low-density lipoprotein （LDL）, serum creatinine （SCr）, urea nitrogen （BUN）, high sensitive reactive protein （hs-CRP）, serum albumin and 24 h urine protein were determined. Results The ratio of patients with arthropathy and Raynaud＇s phenomenon in observation group was significantly higher than that in control group （P〈0.01）. There were significant difference between TC, TG, SCr, serum albumin and 24 h urin protein of two groups （P〈0.05）, while no for other indices （P〉0. 05）. Logistic regression showed that TC, TG, SCr, serum albumin and 24 h urine protein were influencing factor of attacking sub clinical hypothyroidism for patients with systemic lupus erythematosus （P〈0.01）. Conclusion TC, TG, SCr, serum albumin and 24 h urine protein are influencing factor of attacking sub clinieal hypothyroidism for patients with systemic lupus erythematosus and were should inspect these indices to prevent the occurrence of SCH for patients with SLE.

关 键 词：系统性红斑狼疮 亚临床甲状腺功能减退 影响因素 

分 类 号：R593.24[医药卫生—内科学]