老年女性乳腺癌根治术中氟-芬和氯胺酮全凭静脉麻醉的临床效果与安全性  

Clinical effect and safety of Droperidol/Fentanyl and ketamine on radical mastectomy of older women

作　　者：黄仕英[1] 马燕飞[2] 卢冠铭[2] 陆金兰[2] 李天资[2] 陈永诚[2] 胡庆红[2] 王淑娴[2] 余艳蓉[2] 

机构地区：[1]右江民族医学院附属医院麻醉科,广西百色533000 [2]右江民族医学院附属医院乳腺甲状腺外科,广西百色533000

出　　处：《西部医学》2015年第9期1332-1334,共3页Medical Journal of West China

基　　金：广西卫生厅科研基金(Z2010092;Z2014519)

摘　　要：目的观察老年女性乳腺癌根治术中应用氟-芬合剂与氯胺酮全凭静脉麻醉的临床效果及安全性,为后期应用提供参考。方法选取我院收治的80例老年女性乳腺癌患者为研究对象,患者均行乳腺癌根治手术及全凭静脉麻醉,按照麻醉药物不同将患者分为实验组与对照组各40例,对照组行七氟醚静吸复合麻醉,实验组予氟-芬合剂及氯胺酮行全凭静脉麻醉,观察两组患者麻醉前后的一般情况。结果实验组麻醉前至停氧后的血氧饱和度比较,差异有显著性(P<0.01);组间在术后拔管时间、呼吸恢复时间、苏醒时间、苏醒期(疼痛、躁动、导管不耐受)及满意度比较,差异均有统计学意义(均P<0.05)。结论老年女性乳腺癌患者行根治手术时给予氯胺酮及氟-芬合剂进行全凭静脉麻醉的效果显著,患者生命体征平稳,安全性高,值得临床推广应用。Objective To observe the clinical effect and safety of droperidol/Fentanyl and ketamine on radical mastectomy of older women. Methods 80 elderly female patients were selected as the research objects. The patients were treated with breast cancer radical surgery and by venous anesthesia. According to the different anesthetic, the patients were divided into experimental group and control group, 40 cases in each group ;The control group was treated with sevoflurane anesthesia. The experimental group was treated with droperidol/Fentanyl and ketamine. The general indexes were observed before and after anesthesia. Results The blood oxygen saturation of the two groups was significantly different （P〈0.01）. The postoperative extubation time, breathing recovery time, wake up time, the pain, restlessness and catheter intolerance of wake up period, degree of satisfaction of the two group were different （P〈0.05）. Conclusion It is effective and safe to treat female elderly patients with breast cancer radical surgery with droperidol/Fentanyl and ketamine.

关 键 词：氯胺酮 全凭静脉麻醉 老年 乳腺癌根治术 安全性 

分 类 号：R614.24[医药卫生—麻醉学]