乌拉地尔在高血压危象院前急救中的应用价值  

Value of urapidil in pre-hospital emergency for hypertensive emergencies

作　　者：唐力[1] 唐成鈅 

机构地区：[1]双流县第一人民医院急诊科,四川双流620200

出　　处：《西部医学》2015年第9期1379-1381,共3页Medical Journal of West China

摘　　要：目的 探讨乌拉地尔在治疗高血压危象中的临床价值.方法 80例高血压危象患者按入院先后顺序随机分为观察组与对照组各40例.在常规治疗的基础上,对照组应用硝酸甘油10mg加入5％葡萄糖注射液250ml中静脉滴注,滴速20μg/min,根据血压调节滴速;观察组应用盐酸乌拉地尔12.5mg加入0.9％氯化钠注射液250ml中,3～5min内注射完毕,再以50mg盐酸乌拉地尔加入0.9％氯化钠注射液250ml中,以0.1～0.4mg/min静脉滴注,根据血压调节滴速.记录用药前及用药后5、10、20、30、60和120min时的血压（BP）、心率（HR）以及不良反应.结果 给药后各时段的血压改善,组间差异有统计学意义（P＜0.05）;观察组总有效率为91.3％,对照组为81.6％,组间差异亦具有统计学意义（P＜0.05）;HR改变与不良反应发生情况,组间差异无统计学意义（均P＞0.05）.结论 在高血压危象的治疗中,乌拉地尔优于硝酸甘油,具有起效快、效果显著、副作用少等特点.Objective To explore the clinical value of urapidil in pre-hospital emergency for hypertensive emergencies. Methods By order of admission, 80 patients with hypertensive emergencies were randomly divided into observation and control group （n=40）. On the basis of conventional treatment, the observation group was treated with urapidil hydrochloride 12.5mg 0.9% sodium chloride injection 250ml,3 to 5 within the end of the injection, and then added to 50mg urapidil hydrochloride 0.9 % sodium chloride injection 250ml,0.1-0. 4mg/min intravenous drip, drip rate according to blood pressure regulation. The control group was given nitroglycerin 10mg adding 5 % glucose injection 250ml experts intravenous drip rate 20μg/min, according to blood pressure regulation drip rate. 5, 10, 20, 30, 60, 120 min of blood pressure （BP）, heart rate （HR）, and adverse reactions were observed. Results Various time intervals after administration of blood pressure difference was statistically significant between the groups（P〈0.05）. The total efficiency of the observation group and the control group were 91.3% and 81.6%. The difference was statistically significant （P〈 0.05） between the groups. The HR change and the occurrence of adverse reactions were not statistically different between the two groups（P〉0.05）. Conclusion In treatment of hypertensive emergency, urapidil has a feature of rapid onset, significant effect and fewer adverse reactions.

关 键 词：乌拉地尔 硝酸甘油 高血压危象 急救 

分 类 号：R544.11[医药卫生—心血管疾病]