一种那格列奈的合成方法  

A Method of Synthesis of the Nateglinide

作　　者：陈文斌 苏小琴 王涛 盛景新 

机构地区：[1]浙江三门恒康制药有限公司,浙江三门317100 [2]金华爱倍生大药房有限公司,浙江金华321000

出　　处：《山东化工》2015年第17期25-26,共2页Shandong Chemical Industry

摘　　要：D-苯丙氨酸甲酯化生成D-苯丙氨酸甲酯盐酸盐,将反式-4-异丙基环己甲酸与氯甲酸乙酯酰氯化后,加入D-苯丙氨酸甲酯盐酸盐,得到那格列奈甲酯,用氢氧化钠溶液水解后,调酸析晶,得那格列奈,再在丙酮与纯化水作用下转晶型成H型那格列奈。该工艺具有操作简单、高效、收率较高、低毒、对环境友好等优点,总收率74%。Nategiinide was synthesized from D - phenyl alanine＂ as starting material through D - Phenyl alanine methyl ester hydrochloride, Nateglinide methyl ester. In this process, Nateglinide methyl ester was hydrolyzed, acidzed to give Nateglinide, the crystal was changed ro H Nateglinide in acetone and purity water and the total yield was 74%.

关 键 词：D-苯丙氨酸甲酯盐酸盐 那格列奈甲酯 那格列奈 

分 类 号：TQ463[化学工程—制药化工]