头孢拉定缓释制剂的制备及释放特征研究  

Study on Preparation of Cefradine Sustain-release Tablet

作　　者：虢红梅 杨建林[2] 

机构地区：[1]陕西新药技术开发中心,陕西西安710015 [2]宁夏回族自治区西吉县人民医院,宁夏固原756299

出　　处：《中国药业》2015年第17期23-25,共3页China Pharmaceuticals

摘　　要：目的头孢拉定为第1代半合成头孢菌素,为了满足临床特殊用途,进行缓释片的研究。方法采用羟丙甲纤维素(HPMC)、丙烯酸树脂Ⅱ号等缓释材料制备头孢拉定缓释制剂,并考察丙烯酸树脂Ⅱ号含量、剂型、释放介质等对体外累积释放率的影响。结果头孢拉定缓释片体外释药测定结果符合缓释制剂要求。结论头孢拉定缓释片与Higuchi方程拟合较好(在p H=1.2人工胃液中线性回归系数为0.988 7,在p H=7.4人工肠液中为0.993 5),是骨架溶蚀和药物扩散的综合效应过程。Objective Cefradine is the first generation of half synthetic cePhalosPorin. To study the cefradine sustain-release tablet for sPecific usage in the clinic. Methods Sustained-release materials,such as HPMC and Eudragit Ⅱwere adoPted to PrePare the cefra-dine sustained-release dosage forms,and the effects of acrylic resin content,dosage forms and release medium on the cumulative drug release were studied. Results The cefradine sustained-release tablets met the requirements of sustained-release. Conclusion The cefradine sustained-release tablets fit well with the Higuchi equation （ PH=1. 2,R2=0. 988 7,PH=7. 4,R2=0. 994 3 ） ,which is a comPrehensive Process of skeleton dissolution and drug diffusion.

关 键 词：头孢拉定 缓释片 HIGUCHI方程 

分 类 号：TQ460[化学工程—制药化工] R978.11[医药卫生—药品]