4种方案治疗幽门螺杆菌感染的疗效比较  

Efficacy Comparison of 4 Kinds of Treatments for Helicobacter Pylori Infection

作　　者：唐捷 龙云[1,2] 苏强 夏小燕[1,2] 张惠 

机构地区：[1]四川省南充市中心医院 [2]川北医学院第二临床医学院,四川南充637000

出　　处：《中国药业》2015年第17期119-120,共2页China Pharmaceuticals

摘　　要：目的对4种根除幽门螺杆菌(HP)感染的治疗方案进行疗效评价。方法选择2014年就诊的经13C-尿素呼气试验(13C-UBT)或经胃黏膜活检快速尿素酶试验(RUT)确定为HP感染的患者240例,随机分为A、B、C、D组,每组60例,A组给予雷贝拉唑+阿莫西林+克拉霉素治疗;B组给予雷贝拉唑+阿莫西林+左氧氟沙星治疗;C组给予雷贝拉唑+枸橼酸铋钾+阿莫西林+呋喃唑酮治疗;D组给予给予雷贝拉唑+阿莫西林+克拉霉素+双歧杆菌三联活菌肠溶胶囊治疗;疗程均为14 d。结果 A,B,C,D组的HP的根除率分别为61.67%,63.33%,93.33%和91.67%,A组、B组疗效无显著性差异(P>0.05),C组、D组疗效无显著性差异(P>0.05),但A组、B组与C组、D组疗效有显著性差异(P<0.05)。结论传统的三联疗法以及含左氧氟沙星的三联疗法的HP根除率不理想,加用标准剂量的铋制剂或微生态制剂可显著提高HP根除率,是治疗HP感染的新途径。Objective To evaluate the efficacy of four kinds of treatment Programs for the eradication of Helicobacter Pylori infection. Methods 240 cases of Patients identified with H. Pylori infection by the 13C-urea breath test （ 13C-UBT ） or by mucosal bioPsy raPid urease test （ RUT ） were randomly divided into 4 grouPs of A, B, C, D, 60 cases in each grouP. GrouP A were given rabePrazole＋amoxicillin＋clarithromycin; grouP B received rabePrazole＋amoxicillin＋levofloxacin; grouP C were given rabePrazole＋bismuth Potassium citrate＋amoxicillin＋furazolidone; grouP D received rabePrazole＋amoxicillin Plus clarithromycin triPle viable Bifidobacterium enteric-coated caPsules; the treatment course of all grouPs were 14 d. Results The HP eradication rates of the four grouPs were 61. 67%, 63. 33%, 93. 33%, 91. 67% resPectively;the efficacy of grouP A and grouP B had no significant difference （ P 〉 0. 05 ） , and the efficacy of grouP C and grouP D had no significant difference （ P 〉 0. 05 ） , but there was a significant difference between grouP A, B and grouP C, D （ P 〈 0. 05 ） . Conclusion The HP eradication rate of the traditional triPle theraPy and levofloxacin triPle theraPy is not ide-al. Adding a standard dose of bismuth PreParations or Probiotics can significantly imProve the HP eradication rate, and is a new way to treat HP infection.

关 键 词：幽门螺杆菌 根除率 疗效分析 

分 类 号：R969.4[医药卫生—药理学] R975.6[医药卫生—药学]