脓毒症患者血管性血友病因子、抗凝血酶和D二聚体的变化及其临床意义  

Changes of von willebrand Factor,Antithrombin and D-dimer in Patients with Sepsis and its clinical Meanings

作　　者：李智博[1] 温德良[1] 刘卫江[1] 谢长江[1] 熊旭明[1] 

机构地区：[1]广州医科大学附属第二医院重症医学科,广州510260

出　　处：《血栓与止血学》2015年第4期229-231,共3页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的研究脓毒症患者血管性血友病因子(vWF)、抗凝血酶(AT)和D二聚体(D-D)变化,探讨其临床意义。方法 58例脓毒症患者为研究对象,41例健康体检者为对照组。检测血浆vWF、AT和DD水平,同时计算患者的急性生理和慢性健康评分(APACHEⅡ)。结果脓毒症组患者血浆vW F和D-D水平明显高于对照组,血浆AT水平明显低于对照组(P<0.01);脓毒症患者中死亡组vW F和D-D水平明显高于存活组,AT水平明显低于存活组(P<0.01);AT与APACHEⅡ评分呈负相关,相关系数r为-0.839;vWF和D-D与APACHEⅡ呈正相关,相关系数r分别为0.812和0.749。结论 vW F、AT和D-D在脓毒症的发病中起重要的作用,与病情严重程度相关,可作为反映脓毒症预后的指标。Objective To observe the changes of serum von willebrand factor （vWF）, Antithrombin （AT） and D-dimer（D-D） in patients with Sepsis and discuss its clinical value. Methods A total of 58 cases with Spsis were studied. The vWF,ATand D-D, APACHE II score in patients with Sepsis were measured. A to- tal of 41 cases health volunteers were taken as the control. Results The plasma concentrations of vWF and D- D in patients with Sepsis were significantly higher than those in control group（ P 〈 0.01 ） ,but the plasma concentrations of AT were significantly lower than those in control group ; Compared with survive group, the plasma concentrations of vWF and D- D were significantly increased while the AT level decreased （ P 〈 0.01 ） ; The plasma concentrations of AT were negative correlation with APACHE Ⅱ score（ r = -0. 839） ;The plasma concentrations of vWF and D-D were positive correlation with APACHE Ⅱ score （ r = 0.812 and 0.749, respectively）. Conclusion The vWF, AT and D-D may play important roles in pathogenesis of Sepsis, and be correlation with the degree of Sepsis. It is suggested that they may be of importance in predicting the prognosis of patients with Sepsis.

关 键 词：脓毒症 血管性血友病因子 抗凝血酶 D二聚体 

分 类 号：R446[医药卫生—诊断学]