二丙酸倍氯米松和糖皮质激素类药物灌肠治疗溃疡性结肠炎的疗效对比分析  

Comparison of effect of enema of beclomethasone dipropionate and glucocorticoid drugs in treating ulcerative colitis

作　　者：董治华 隋典朋[2] 王娜[2] 

机构地区：[1]重庆市綦江区人民医院消化内科,401420 [2]重庆市綦江区人民医院科教部,401420

出　　处：《检验医学与临床》2015年第17期2494-2496,2499,共4页Laboratory Medicine and Clinic

基　　金：国家卫生部资助项目(201202006-08)

摘　　要：目的比较二丙酸倍氯米松(BDP)和糖皮质激素类药物灌肠治疗溃疡性结肠炎(UC)的疗效及其影响因素。方法选取以2010年3月至2013年6月于该院消化内科门诊或者住院就诊的80例UC患者为研究对象,按照治疗方式的不同以随机数字表法分为传统组和BDP治疗组,每组各40例,对比两组患者的临床疗效,采取多因素Logistic分析影响治疗疗效的因素。结果传统组患者治疗后显效12例,有效16例,总体有效率为70.00%(28/40),而BDP治疗组患者的总体治疗有效率为90.00%(36/40),明显高于传统组(P<0.05);多因素Logistic回归结果显示,C反应蛋白(OR=3.81,P=0.002),血小板(OR=2.01,P=0.031),药物不良反应(OR=2.34,P=0.017)和重型(OR=2.54,P=0.014)是影响传统组治疗疗效的风险因素;而BDP治疗组治疗效果的风险因素分别是重型(OR=3.11,P=0.025)和C反应蛋白(OR=2.86,P=0.004)。结论 BDP对UC的疗效明显优于传统糖皮质激素类药物,影响其疗效的因素主要是疾病的严重程度和C反应蛋白水平。Objective To compare the effect of enema of beclomethasone dipropionat（BDP） and glucocorticoid drugs in treating ulcerative colitis（UC） and its influencing factors .Methods 80 cases of UC in our hospital from March 2010 to June 2013 were selected as the research subjects ,and randomly divided into the conventional therapy group and the BDP treatment group according to the different treatment modes ,40 cases in each group .The clinical curative effects were compared between the two groups and the influencing factors were analyzed by Logistic multiva‐riate analysis .Results In the conventional therapy group after treatment ,12 cases were significantly effective and 16 cases were effective with the total effective rate of 70 .00% （28/40） ,while the total effective rate in the BDP treat‐ment group was 90 .00% （36/40） ,which was significantly higher than that in the conventional therapy group （P〈0 .05）;the multivariate Logistic regression analysis results showed that ,C‐reactive protein （OR=3 .81 ,P=0 .002） , platelet （OR=2 .01 ,P=0 .031） ,adverse drug reactions（OR= 2 .34 ,P=0 .017） and severe type （OR= 2 .54 ,P=0 .014） were the risk factors affecting the therapeutic effect in the conventional therapy group;severe type （OR=3 .11 ,P=0 .025） and C‐reactive protein（OR=2 .86 ,P=0 .004） were the risk factors in the BDP treatment group . Conclusion The effect of BDP in treating UC is obviously superior to the traditional glucocorticoid drugs ,and the main factors affecting effect are the severity of disease and C‐reaction protein level .

关 键 词：二丙酸倍氯米松 糖皮质激素 溃疡性结肠炎 影响因素 

分 类 号：R977.11[医药卫生—药品]