泌尿系统感染患者菌群分布及药敏分析  

A retrospective analysis of the bacterial flora distribution and drug susceptibility for the patients with urinary tract infections

作　　者：陈玲[1] 杨传松[1] 肖金[1] 

机构地区：[1]四川省江油市人民医院检验科,621700

出　　处：《检验医学与临床》2015年第17期2616-2618,共3页Laboratory Medicine and Clinic

摘　　要：目的回顾性分析近2年该院泌尿系统感染患者的菌群分布情况并进行药敏情况分析,为临床疾病诊治时合理使用抗菌药物提供参考。方法整理收集2013年1月至2014年12月在该院确诊为泌尿系统感染的186例患者临床相关资料,并对资料进行综合分析。结果菌群分离率结果显示,186例患者尿液标本中分离的菌群分布前5名的依次为大肠埃希菌、肺炎克雷伯菌、变形杆菌、不动杆菌及凝固酶阴性葡萄球菌,分离率分别为74.19%、8.60%、6.45%、4.84%和3.76%。药敏结果显示,大肠埃希菌对阿米卡星、呋喃妥因和亚胺培南的耐药率分别为15.22%、5.07%和2.17%;肺炎克雷伯菌对亚胺培南、阿米卡星和呋喃妥因的耐药率分别为18.75%、12.50%和6.25%,其他药物的耐药率均偏高;第3代头孢类抗菌药物的抗菌稳定性显著高于第1代和第2代产品。结论革兰染色阴性杆菌是泌尿系统感染性疾病主要的致病菌,临床医生应该根据患者药敏情况合理使用抗菌药物,避免耐药菌株的产生。Objective To retrospectively analyze the bacterial flora distribution and drug resistance situation in the patients with urinary tract infections in our hospital in the recent two years to provide reference for clinical ration‐al use of antibacterial drugs in the diagnosis and treatment of clinical diseases .Methods The clinically relevant data of 186 cases of urinary tract infections in our hospital from January 2013 to December 2014 were collected and per‐formed the comprehensive analysis .Results The bacterial flora isolated rate showed that the top five of isolated bac‐terial flora were in turn E .Coli ,Klebsiella pneumoniae ,proteus ,acinetobacter and coagulase negative staphylococcus , the isolation rates were 74 .19% ,8 .60% ,6 .45% ,4 .84% and 3 .76% respectively .The drug susceptibility results showed that ,drug resistance of Escherichia coli to Amikacin ,nitrofurantoin ,imipenem were respectively 15 .22% , 5 .07% and 2 .17% ;the drug resistance rates of Klebsiella pneumoniae to imipenem ,amikacin and nitrofurantoin were 18 .75% ,12 .50% and 6 .25% respectively ,which to other drugs were high;the antibacterial stability of third genera‐tion cephalosporins was significantly higher than that of the first generation and the second generation cephalospo‐rins .Conclusion Gram negative bacilli were the main pathogenic bacteria of urinary system infection diseases ,clini‐cians should rationally use the antibacterial drugs according to the drug susceptibility situation to avoid the generation of drug resistant strains .

关 键 词：泌尿系统 革兰阴性菌 耐药率 抗菌药物 

分 类 号：R978.1[医药卫生—药品]