A Retrospective Study of Spectrum of Nevirapine Induced Cutaneous Drug Reactions in HIV Positive Patients  

作　　者：Leelavathy Budamakuntla Nirmala Challa Prabhakar Basappa Chandrashekhara Puttappa 

机构地区：[1]Department of Dermatology, Bowring and Lady Curzon Hospital. Rangalore Medical College and Research Institute, RajivGandhi University of Health Sciences Bangalore, Karnataka 560001, lndia [2]Department of Medicine, Bowring and Lady Curzon Hospital. Bangalore Medical College and Research Institute, Rajiv GandhiUniversity of Health Sciences Bangalore, Karnataka 560001, India

出　　处：《Journal of US-China Medical Science》2015年第2期85-89,共5页美中医学（英文版）

摘　　要：BACKGROUND： Nevirapine, a NNRTI （non-nucleoside reverse transcriptase inhibitor）, is most commonly used as a part of the combination therapy for HIV （human immunodeficiency virus） infection because of its efficacy and good tolerability. But it is the major culprit in causing adverse drug reactions ranging from mild maculopapular rash to severe toxic epidermal necrolysis. AIM： To observe the spectrum of adverse cutaneous reactions to Nevirapine. METHODOLOGY： This is a retrospective study from the year 2006-2013. RESULTS： 120 cases presented with adverse cutaneous reactions to NVP （Nevirapine）. Out of 120 patients, females outnumbered males （68：52）. Majority of them were in the age group of 31-40 years. 63 （52.5%） patients developed maculopapular rash, 37 （30.8%） cases of SJS/TEN （Steven Johnson Syndrome/Toxic epidermal necrolysis）, 13 （10.8%） patients developed diffuse erythema, urticarial rash in 3 （2.5%）, angioedema in 3 （2.5%）, 1 （0.9%） developed serum sickness like reaction. CONCLUSION： Managing HIV infection is a double edged sword, and the benefits of ART have to be balanced against the risks of drug toxicity.

关 键 词：NEVIRAPINE adverse drug reactions anti retroviral therapy toxic epidermal necrolysis Steven Johnson. 

分 类 号：TQ464[化学工程—制药化工] S858.235.3[农业科学—临床兽医学]