肾结石患者身体质量指数与24h尿液化学成分的相关性  

The correlation between the body mass index （BMI） and 24-hour urine chemical composition in the population of kidney stone patients

作　　者：葛广成[1] 李中兴[1] 冯瑞[1] 吴丹[1] 沈斌[1] 王星[1] 

机构地区：[1]镇江市第二人民医院泌尿外科,江苏镇江212000

出　　处：《国际泌尿系统杂志》2015年第5期648-652,共5页International Journal of Urology and Nephrology

基　　金：镇江市卫生局重点科技项目（编号：2013SH085）

摘　　要：目的 研究肾结石患者的身体质量指数（BMI）和24h尿液化学成分之间的关系.方法 收集220例肾结石患者的尿液进行24h尿化学成分分析.利用四分位法,分别将男女患者按照BMI进行分层.使用单因素方差分析法和多重线性回归分析法,分析BMI和24h尿液化学成分各数值间的相互关系.结果 单因素方差分析结果显示,在男性患者中,BMI的增加与尿钠、钙、柠檬酸、尿酸、镁、草酸钙的增加呈正比例关系,与pH值的下降呈反比例关系.在女性患者中,BMI与尿钠、尿酸、草酸的增加呈正比例关系,与pH值的下降呈反比例关系.多重线性回归分析显示：在男性患者中,BMI与尿钠、草酸钙的增加以及pH值的降低呈正比例关系;在女性患者中,BMI和尿钠、肌酐、磷酸盐、柠檬酸以及硫酸盐呈正比例关系,与尿柠檬酸、硫酸盐呈反比关系.结论 本研究的结果显示,BMI的增加和许多肾结石患病风险因素有显著相关性,包括：男性患者中增加的尿钠和尿酸、降低的pH;女性患者中升高的尿酸、尿钠和降低的尿柠檬酸.建议肾结石患者积极减肥、低盐饮食、少食动物蛋白。Objectives To assess the relationship between the body mass index（BMI） and 24-hour urine chemical composition in the population of kidney stone patients.Methods To collect and analysis 220 cases of kidney stone patients＇24-hour urine.Patients were divided into quartiles of body mass index and stratified by gender.Using bivariate and multivariate linear regression explored the relationship between body mass index（BMI） and urine parameters.Results The bivariate analysis shows that BMI increased with urinary sodium,calcium,citrate,uric acid,magnesium,calcium oxalate,uric acid increased significantly correlated,pH value decreased with a significant negative correlation in men.BMI was associated with significantly increased urinary sodium,uric acid,oxalic acid increased significantly positively correlated,pH decreased with a significant negative correlation in women.The multivariate linear regression＇s results confirmed that BMI was associated only with increases in sodium and calcium oxalate and decrease in pH in men.In women,multivariate analysis demonstrated positive association between BMI and urine sodium,creatinine,and phosphate and a negative relationship with urine citrate and sulfate.Conclusions The results of this study show that the BMI increases and risk factors of kidney stone was significantly correlated,including：increased urinary sodium and uric acid,reduced pH in men;increasing urine uric acid,sodium,and decreasing urine citrate in women.Recommended in patients with urinary calculus actively lose weight,low -salt diet,and low animal protein diet.

关 键 词：肾结石 人体质量指数 尿 

分 类 号：R692.4[医药卫生—泌尿科学]