莫西沙星与多西环素治疗恙虫病疗效比较  

Moxifloxacin versus doxycycline for tsutsugamushi disease

作　　者：薛聃[1] 矫捷 王惠枢[1] 林琼[1] 

机构地区：[1]福建医科大学附属协和医院呼吸内科,福州350001 [2]福建中医药大学附属福鼎医院呼吸内科,福建福安355200

出　　处：《中华实用诊断与治疗杂志》2015年第9期921-922,926,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：福建省卫生厅青年课题(2012117)

摘　　要：目的比较莫西沙星与多西环素治疗恙虫病的疗效。方法 54例恙虫病患者依据初始用药分为莫西沙星组24例和多西环素组30例,分别经验性应用莫西沙星和多西环素治疗,比较2组退热时间,治疗48、72h退热率及疗效。结果莫西沙星组治疗有效率(41.7%)低于多西环素组(96.7%)(P<0.05),治疗有效者退热时间[(84.4±15.9)h]较多西环素组[(37.8±17.7)h]长(P<0.05),48h退热率(0)、72h退热率(16.7%)低于多西环素组(73.3%、90.0%)(P<0.05)。结论与多西环素比较,莫西沙星治疗恙虫病起效慢,有效率低,不宜作为恙虫病的一线治疗用药。Objective To compare the efficacy of moxifloxacin versus doxycycline on tsutsugamushi disease. Methods Fifty-four patients with tsutsugamushi disease were divided into moxifloxacin group （n=24） and doxycycline group （n=30） according to initial antibiotics used. The effective rate and defervescence rate were compared between two groups after 48- and 72-hour treatment. Results The effective rate was significantly lower in moxifloxacin group （41.7%） than that in doxycycline group （96. 7%） （P〈0.05）. The defervescence time was significantly longer in moxifloxacin group （（84.4±15.9） h） than that in doxycycline group （（37.8±17.7） h） （P〈0.05）. The deferveseence rates were lower in moxifloxacin group （0, 16.7 %） than those in doxyeycline group （73.7%, 90.0%） after 48- and 72-hour treatment （P〈 0.05）. Conclusion Because moxifloxacin has lower effective rate and takes effect more slowly than doxyeycline, it should not be used as the first-line drug for tsutsugamushi disease.

关 键 词：恙虫病 莫西沙星 多西环素 

分 类 号：R513.2[医药卫生—内科学]