探讨不同性别冠心病患者部分危险因素与冠状动脉病变的关系  

To discuss the relationship between part of risk factors and the characters of coronary artery lesion of different gender patients with coronary heart disease

作　　者：王慧清[1] 王琰娜[1] 解泽宙[1] 

机构地区：[1]大连大学附属中山医院循环内科,116001

出　　处：《中国医师进修杂志》2015年第9期668-671,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨不同性别冠心病患者部分危险因素和冠状动脉病变特点的关系。方法选择经冠状动脉造影诊断为冠心病的患者208例，男122例（男性组），女86例（女性组），比较不同性别冠心病患者的临床资料与冠状动脉病变特征，分析不同性别冠心病患者的独立危险因素。结果女性组发病年龄较男性组晚[（69．22±10．12）岁比（62．80±11．34）岁]（P=0．000）。女性组高血压和糖尿病患病率高于男性组[83．7％（72／86）比63．1％（77／122），53．5％（46／86）比32．8％（40／122）]，女性组总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）比平高于男性组[（5．16±1．26）mmol／L比（4．60±1．23）mmol／L，（1．16±0．27）mmol／L比（1．05±0．27）mmol／L，（3．17±1．16）mmol／L比（2．74±1．06）mmol／L]，尿酸（UA）水平低于男性组[（319．83±90．05）μmol／L比（357．91±98．51）μmol／L]，差异均有统计学意义（P〈0．01）。两组三酰甘油（TG）水平比较差异无统计学意义[（1．91±1．23）mmol／L比（1．75±0．97）mmol／L]（P=0．298）。以冠状动脉病变为因变量，以TC、TG、HDL—C、LDL-C、UA、年龄、高血压和糖尿病为自变量，进行Logistic多元逐步回归分析，结果显示，年龄和糖尿病为不同性别冠心病患者的独立危险因素（P〈0．01或〈0．05）。结论不同性别冠心病患者具有不同的危险因素，冠状动脉病变特点相似。糖尿病是不同性别冠心病患者最重要的独立危险因素，对于女性合并多重危险因素患者尤其重视。Objective To discuss the relationship between part of risk factors and the characters of coronary artery lesion of different gender patients with coronary heart disease（CHD）. Methods Two hundred and eight patients who were diagnosed CHD by coronary angiography （CAG） were selected. All patients were divided into male group （122 cases） and female group （86 cases）. The characters of CHD and part of clinical data in different gender CHD patients were compared and analyzed. The independent risk factors of different gender CHD patients were analyzed. Results The age of onset in female group was later than male group： （69.22 ± 10.12） years vs.（62.80 ± 11.34） years, P = 0.000. The incidence rate of hypertension and diabetes in female group were significantly higher than those in male group： 83.7%（72/86） vs. 63.1%（77/122）, 53.5% （46/86） vs, 32.8%（40/122）; and the levels of total cholesterol（TC）, high density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C） in female group were significantly higher than those in male group： （5.16 ± 1.26） mmol/L vs. （4.60± 1.23） mmol/L,（1.16 ± 0.27） mmol/L vs. （1.05 ± 0.27） mmol/L, （3.17 ± 1.16） mmol/L vs. （2.74±1.06） mmol/L; the level of uric acid （UA） in female group was significantly lower than that in male group： （319.83 ± 90.05）μmol/L vs. （357.91 ± 98.51） μmol/L, there were significantly differences （P 〈 0.01）. The level of trigalloyl glycerol （TG） in two groups had no significant difference： （1.91 ± 1.23） mmol/L vs. （1.75± 0.97） mmol/L, P = 0.298. Logistic regression analysis showed that age and diabetes were the risk factors of CHD in different gender （P 〈 0.01 or 〈 0.05）. Conclusions There are different risk factors between different gender CHD patients, while the coronary artery lesion is similar. Diabetes is the most important independent risk factor of different gender CHD patients, which is more important for female

关 键 词：冠状动脉疾病 危险因素 性别因素 

分 类 号：R541.4[医药卫生—心血管疾病]