冠状动脉粥样硬化性心脏病患者血浆左旋肉碱水平变化研究  

Level of plasma L-carnitine in patients with coronary heart disease

作　　者：陈亚红[1] 刘梅林[2] 乔松[1] 王立羽[1] 李亚瑞[1] 

机构地区：[1]北京市第二医院心脑血管科,10003l [2]北京大学第一医院老年科,10003l

出　　处：《中国医药》2015年第9期1253-1257,共5页China Medicine

基　　金：国家科技支撑计划（2012BAl37800）

摘　　要：目的 检测冠状动脉粥样硬化性心脏病（冠心病）患者血浆左旋肉碱水平.方法 纳入2004年10月至2006年3月于北京大学第一医院住院的冠心病患者48例（冠心病组）和非冠心病患者27例（非冠心病组）.检测患者血浆总左旋肉碱、游离左旋肉碱水平,计算脂酰左旋肉碱及脂酰左旋肉碱占总左旋肉碱百分比.结果 冠心病组血浆总左旋肉碱水平高于非冠心病组,差异有统计学意义[（63.1±11.6）μmol/L比（51.6±10.9）μmol/L] （P ＜0.05）,游离左旋肉碱、脂酰左旋肉碱、脂酰左旋肉碱/总左旋肉碱在冠心病组和非冠心病组间差异无统计学意义[（53.4±11.7） μmol/L比（51.0±3.8）μmol/L、（12.3±5.0） μmol/L比（8.3 ±2.3）μmol/L、（19.4±7.2）％比（13.8±2.5）％]（P＞0.05）.多重线性回归结果表明冠心病、高血压及年龄为血浆总左旋肉碱水平影响因素（复相关系数R2为0.428,校正复相关系数R2为0.374,P＜0.01）.51～60岁患者脂酰左旋肉碱/总左旋肉碱明显高于61 ～70岁患者[（26.3±l3.3）％比（13.6±3.2）％],差异有统计学意义（P＜0.05）.高血压患者与非高血压患者间总左旋肉碱、游离左旋肉碱、脂酰左旋肉碱及脂酰左旋肉碱/总左旋肉碱差异无统计学意义（P＞0.05）.结论冠心病患者血浆总左旋肉碱水平升高.Objective To explore the level of plasma L-carnitine in patients with coronary heart disease （CHD）.Methods Totally 75 patients including 48 cases with CHD （CHD group） and 27 cases without CHD （non-CHD group） were enrolled.The levels of total and free L-carnitine were measured,then the percentage of acyl L-carnitine and acyl L-carnitin for total L-carnitine in plasma were calculated and compared between the two groups.Results The plasma level of total L-carnitine in CHD group was significantly higher than that in non-CHD group [（63.1 ± 11.6） μmol/l vs （51.6 ± 10.9） μmol/l] （P 〈 0.05）,while no significant differences of free L-carnitine,acyl L-carnitine and percentage of acyl carnitin for total L-carnitine were found between CHD group and non-CHD group [（53.4± 11.7） μmol/L vs （51.0±3.8） μmoL/L,（12.3±5.0） μmol/L vs （8.3 ± 2.3） μmol/L,（19.4 ± 7.2） % vs （13.8 ± 2.5） %] （P 〉 0.05）.Multiple linear regression showed that CHD,hypertension and age were the influence factors of total L-carnitine （multiple correlation coefficient R2 was 0.428,adjusted multiple correlation coefficient R2 was 0.374,P 〈 0.01）.The percentage of acyl L-carnitine for total L-carnitine was significantly higher in 51-60 years old patients than that in 61-70 years old patients [（26.3 ± 13.3） % vs （13.6 ± 3.2） %] （P 〈 0.05）.No significant differences of total L-carnitine,free L-carnitine,acyl L-carnitine and percentage of acyl carnitin for total L-carnitine were found between hypertension and non hypertension patients （P 〉 0.05）.Conclusion The level of plasma total L-carnitine is increased significantly in CHD patients.

关 键 词：冠状动脉疾病 左旋肉碱 年龄 高血压 

分 类 号：R541.4[医药卫生—心血管疾病]