补肾固齿丸治疗牙周炎的Meta分析  

Effects of bushenguchiwan on treatment of periodontitis: a Meta analysis

作　　者：吕宗凯 郑杨灿[3,2] 杨映阳 杜胜男 冯辉[1,2] 邓礼辉 

机构地区：[1]南充市中心医院口腔科 [2]川北医学院第二临床医学院,637000 [3]南充市中心医院泌尿外科

出　　处：《中华口腔医学研究杂志（电子版）》2015年第4期38-41,共4页Chinese Journal of Stomatological Research(Electronic Edition)

摘　　要：目的评价补肾固齿丸在牙周炎治疗中的疗效及安全性。方法电子检索中国生物医学文献数据库(CBM,1978年1月至2015年4月)、Medline(1950年1月至2015年4月)、Cochrane图书馆临床随机对照试验库(CENTRAL,2015年第4期),收集有关补肾固齿丸治疗牙周炎的临床随机对照试验与临床对照试验。两位研究者采用CONSORT质量评价标准对文献进行质量评价并提取其关于临床有效率、牙周探诊深度(PD)和牙槽骨平均灰度值的数据后,采用Revman5.3.5进行Meta分析。结果最终纳入8篇文献,共498例患者。Meta分析显示,补肾固齿丸能有效缓解牙周炎患者的症状(OR=3.98,95%CI=[2.23,7.10],P<0.05),明显降低PD(WMD=-0.75,95%CI=[-1.42,-0.09],P=0.03),但在促进牙周骨组织再生方面,差异无统计学意义(WMD=1.79,95%CI=[-0.38,3.95],P=0.11)。结论补肾固齿丸对牙周炎有显著的治疗作用,值得在临床上推广。Objective To assess the effect and safety of Bushenguchiwan on the treatment of periodontitis. Methods The electronic search was conducted in CBM （1978 Jan-2015 Apr）, Medline （OVID, 1950 Jan-2015 Apr）, and CENTRAL （2015, Issue 4）. The clinical randomized controlled trials and clinical controlled trials involved the topic were selected. Two investigators evaluated the quality of the included trials with CONSORT statement and the data about clinical efficacy rate, periodontal probing depth and mean grey values were collected for Meta analysis with Revman 5.3.5. Results Eight publications met the inclusion criteria and 498 patients were involved. Meta analysis showed Bushenguchiwan significantly relieved the symptoms of periodontitis （OR=3.98, 95% CI=[2.23,7.10], P﹤0.05）, and decreased probing depth （PD） （WMD = -0.75, 95% CI = [-1.42,-0.09], P= 0.03）, without promoting bone regeneration （WMD=1.79, 95% CI=[-0.38,3.95], P=0.11）. Conclusion Bushenguchiwan is effective on the treatment of periodontitis and is worth being promoted.

关 键 词：补肾固齿丸 牙周炎 META分析 系统评价 

分 类 号：R276.8[医药卫生—中医五官科学]