不同人群中新型呼肠病毒既往感染状况调查  

Serological survey of past infection with a novel reovirus in different populations

作　　者：胡燕[1] 貌达 刘泽[1] 姜棋予 谢国明[1] 白冰珂[1] 

机构地区：[1]解放军第三○二医院实验技术研究保障中心,北京100039 [2]中国食品药品检定研究院艾滋病性病病毒疫苗室,北京100050

出　　处：《传染病信息》2015年第4期207-209,共3页Infectious Disease Information

基　　金：国家自然基金青年基金(81000735)

摘　　要：目的调查不同人群中新型呼肠病毒既往感染情况。方法选取健康人群以及手足口病、腹泻、麻疹、乙型肝炎等患者的血清标本,利用微量中和试验检测其血清标本中新型呼肠病毒IgG抗体。结果中和试验结果表明,健康人群中新型呼肠病毒IgG抗体阳性率为29.90%,抗体滴度的中位数为1:32;手足口病患者中抗体阳性率为70.83%,抗体滴度的中位数为1:64;乙型肝炎和麻疹患者抗体阳性率分别为90.22%和90.70%,抗体滴度的中位数均为1:128;腹泻患者中抗体阳性率和抗体滴度的中位数均最高,分别为100%和1:256。结论健康人群与不同疾病患者中薪型呼肠病毒特异性IgG抗体阳性率及滴度存在显著差异。Objective To evaluate the prevalence of past infection with a novel reovirus in different populations. Methods The serum samples were taken from 97 healthy people and 219 patients with hand, foot and mouth disease （HFMD）, diarrhea, measles and hepatitis B treated in our hospital. The prevalence of the novel reovirus-specific IgG antibody in sera was detected by using a neutraliza-tion assay. Results The neutralization assay demonstrated that the positive rates of the novel reovirus-specific IgG antibody were 29.90%in healthy controls, 70.83%in HFMD group, 90.22%in hepatitis B group, 90.70%in measles group and 100%in diarrhea group, and the median IgG antibody titers were 1∶32, 1∶64, 1∶128, 1∶128 and 1∶256 in those groups respectively. Conclusions The positive rates and titers of a novel reovirus-specific IgG antibody are significantly different between the healthy population and patients with different diseases.

关 键 词：呼肠病毒科感染 血清分型 中和试验 

分 类 号：R512.99[医药卫生—内科学]