参桂益心汤治疗慢性心力衰竭临床效果及对超声学指标的影响  

Shengui Yixin Decoction on Patients with Chronic Heart Failure and Its Effect on Cardiac Ultrasound Index

作　　者：冯庆涛[1] 

机构地区：[1]河北省中医院,石家庄050011

出　　处：《中国实验方剂学杂志》2015年第17期165-168,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河北省中医药管理局2014年度科研计划项目(2014025)

摘　　要：目的：研究参桂益心汤治疗慢性心力衰竭患者临床效果及其对心脏超声学指标的影响。方法：124例心力衰竭患者根据入院时间的奇偶数随机分为对照组（n=50）和治疗组（n=74）,对照组采用去除各种诱发因素、调整生活方式,对有焦虑、抑郁的患者及时进行心理干预,药物治疗包括给予利尿剂,血管紧张素转换酶抑制剂（ACEI）类药物,β受体阻滞剂,醛固酮受体拮抗剂,血管紧张素受体拮抗剂（ARB）,地高辛等药物治疗。治疗组在对照组基础上,使用参桂益心汤,口服,4片/次,3次·d-1,2周为1个疗程,服用4周。采用Lee氏心力衰竭评分对治疗效果进行评价,观察患者N末端利钠肽（NTpro BNP）,心脏肌钙蛋白（c Tn）,半乳糖凝集素-3水平,生活质量采用36条简明健康问卷（SF-36）和明尼苏达心衰生活质量量表（MLHFQ）进行评价,超声检测患者心排血量（CO）,每搏输出量（SV）,左室射血分数（LVEF）,左室舒张末期内径（LVDD）和心脏指数（CI）。结果：两组治疗4周后,治疗组疗效与对照组比较,差异有统计学意义（P〈0.05）。治疗组总有效率与对照组比较,差异有统计学意义（P〈0.05）。对照组治疗后NT-pro BNP,c Tn,半乳糖凝集素-3,Lee氏评分与治疗前比较,差异有统计学意义（P〈0.05）。治疗组治疗后NT-pro BNP,c Tn,半乳糖凝集素-3,Lee氏评分与治疗前、对照组治疗后比较,差异有统计学意义（P〈0.05）。对照组治疗后SF-36,MLHFQ评分与治疗前比较,差异有统计学意义（P〈0.05）,治疗组治疗后SF-36,MLHFQ评分与治疗前、对照组治疗后比较,差异有统计学意义（P〈0.05）。对照组治疗后SV,CO,LVEF,LVDD,CI水平与治疗前比较,差异有统计学意义（P〈0.05）。治疗组治疗后SV,CO,LVEF,LVDD,CI水平与治疗前、对照组治疗后比较,差异有统计学意义（P〈0.05）。结论：参桂益心汤可以用于冠心病、高血压性心脏病所致Objective： To study the clinical effect of Shengui Yixin decoction on patients with chronic heart failure and its effect on cardiac ultrasound index. Method： Totally one hundred and twenty-four cases of heart failure patients were divided randomly into the control group（ n = 50） and the treatment group（ n = 74）according to the odevity of their admission time. The control group received the therapies of removing inducing factors,adjusting lifestyle,providing psychological intervention for those with anxiety and depression and taking drugs,including diuretics,angiotensin converting enzyme inhibitors（ ACEI） drugs,beta blockers,aldosterone receptor antagonist,angiotensin receptor antagorists（ ARB）,digoxin. The treatment group was given Shengui Yixin decoction for 4 weeks,4 tablets / time,3 times / day,with 2 weeks in 1 courses of treatment,in addition to the therapies of the control group. The therapeutic effect was evaluated by Lee＇s heart failure score,the N terminus natriuretic peptide（ NT-pro BNP）,cardiac troponin（ c Tn） and galectin-3 were observed. The life quality was evaluated by the 36-item short form health questionnaire（ SF-36） and the Minnesota living with heart failure quality scale（ MLHFQ）. The patients＇ cardiac output（ CO）,stroke volume（ SV）,left ventricular ejection fraction（ LVEF）,left ventricular end diastolic diameterleft（ LVDD） and cardiac index（ CI） were detected by ultrasound.Result： After the four-week treatment,the efficacy of the treatment group was significant statistically compared with the control group（ P〈0. 05）. The total effective rate of the treatment group was significant statistically compared with the control group（ P〈0. 05）. NT-pro BNP,c Tn,galectin-3 and Lee score in the control group were significant statistically compared with that before the treatment（ P〈0. 05）. NT-pro BNP,c Tn,galectin-3 and Lee＇s score in the treatment group after the treatment were significant statistically compared with the co

关 键 词：慢性心力衰竭 参桂益心汤 生活质量 超声检查 多普勒 

分 类 号：R287.6[医药卫生—中药学]