中药不同途径联合给药治疗儿童支气管哮喘寒热错杂证发作期55例  

Combined Administration of Traditional Chinese Medicines Through Different Approaches in Treating 55 Cases of Child Bronchial Asthma in Episodes of Intermingled Cold and Heat Symptoms

作　　者：黄越[1] 廖伯年[1] 王建军[1] 刘崇海[1] 

机构地区：[1]川北医学院附属医院,四川南充637000

出　　处：《中国实验方剂学杂志》2015年第17期177-180,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：南充市科技局计划项目(13A0027)

摘　　要：目的:观察宣肺平喘汤内服和哮喘I方穴位敷贴加离子导入的多途径给药治疗儿童支气管哮喘(寒热错杂证)发作期的临床疗效及对患者白细胞介素-4(IL-4),γ-干扰素(IFN-γ),免疫球蛋白E(Ig E)的影响。方法:采用随机按数字表法将110例患者分为对照组和观察组各55例。对照组采用宣肺平喘汤内服治疗,观察组在对照组治疗的基础上加用哮喘I方穴位敷贴加离子导入。两组疗程均为2周。记录两组患儿咳嗽、喘息和肺部哮鸣音消失时间;检测治疗前后肺功能,包括最大呼气流量(PEF)和第1秒钟用力呼气容积与用力肺活量比值(FEV1/FVC);采用哮喘控制问卷(ACQ)评价哮喘控制情况;检测治疗前后IL-4,IFN-γ和Ig E水平。结果:治疗后观察组临床显效率为92.73%,对照组为78.18%,观察组优于对照组(P<0.05);观察组在咳嗽、喘息消失、肺部哮鸣音消失时间均明显短于对照组(P<0.01);治疗后观察组PEF和FEV1/FVC均高于对照组(P<0.01);治疗后观察组IL-4和Ig E水平低于对照组,IFN-γ水平高于对照组(P<0.01);经卡方检验,观察组哮喘控制情况优于对照组(P<0.05)。结论:宣肺平喘汤内服和哮喘I方穴位敷贴加离子导入的多途径给药治疗儿童支气管哮喘(寒热错杂证)发作期的临床疗效优于单一中药内服,其作用机制可能是通过调节免疫系统紊乱,减轻炎症反应来实现的。Objective： To observe the clinical efficacy of Xuanfei Pingchuan decoction for oral administration combined with asthma I formula for acupoint sticking and iontophoresiss in treating child asthma（ intermingled cold and heat symptoms） and their effect on interleukin-4（ IL-4）,γ-interferon（ IFN-γ） and immunoglobulin E（ Ig E）. Method： Totally 110 patients with bronchial asthma（ intermingled cold and heat symptoms） were divided into the control group（ 55 cases） and the observation group（ 55 cases） by random number table. The control group orally took Xuanfei Pingchuan decoction. The observation group received acupoint sticking and iontophoresiss of Xuanfei Pingchuan decoction. The course of treatment was 2 weeks for both groups.The time of cough,wheeze and pulmonary wheezing extinction time were recorded. Before and after the treatment,lung function,peak expiratory flow（ PEF）,specific value of the first second forced expiratory volume and forced vital capacity（ FEV1/ FVC） were detected. The control of asthma was evaluated by asthma control questionnaire（ ACQ）. Serum IL-4,IFN-γ and Ig E were detected before and after the treatment. Result： The obvious effective rate was 92. 73% in the observation group,which was superior to 78. 18% in the control group（ P〈0. 05）. The extinction times of coughing,wheezing and lung wheezing sound in the observation group were obviously shorter than that in the control group（ P〈0. 01）. After the treatment,PEF and FEV1/ FVC in the observation group were higher than that in the control group（ P〈0. 01）. After the treatment,serum IL-4 and Ig E in the observation group were lower than that in the control group,but with higher IFN-γ than the control group（ P〈0. 01）. According to the chi-square test,the asthma controlling effect in the observation group was better than that in the control group（ P〈0. 05）. Conclusion： The curative effect of Xuanfei Pingchuan decoction for oral administration combined with asthma I f

关 键 词：支气管哮喘 儿童 寒热错杂 宣肺平喘汤 哮喘I方 离子导入 

分 类 号：R287[医药卫生—中药学]