异戊烯基黄酮的生物活性及构效关系  

Biological Activity and Structure-Activity Relationship of Prenylated Flavonoids

作　　者：党延启 段菊[1] 倪荣镇 马婧[1] 甘我挺[1] 凌霜[1] 许锦文[1] 

机构地区：[1]上海中医药大学穆拉德中药现代化研究中心,上海201203

出　　处：《中国实验方剂学杂志》2015年第17期213-218,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81274130);国家自然科学基金青年科学基金项目(81102532);教育部高等学校博士学科点专项科研基金(博导类)项目(20113107110006);上海市教委科研创新项目(自然科学类)重点项目(12ZZ122);上海市教委085项目高等教育内涵建设基金项目(085ZY1202)

摘　　要：异戊烯基黄酮是黄酮类化合物中的一个分支,特点是在黄酮类化合物的骨架上存在异戊烯基侧链。根据异戊烯基结合位点、数量及结构类型,异戊烯基黄酮分为:3号位异戊烯基黄酮,5号位异戊烯基黄酮,6号位异戊烯基黄酮,8号位异戊烯基黄酮、多侧链异戊烯基黄酮、吡喃环异戊烯基黄酮和薰衣草基异戊烯基黄酮7种。异戊烯基黄酮存在广泛的生物活性,特别是在促进干细胞分化、抗炎和免疫调节、心血管保护、改善代谢性疾病、改善骨质疏松、神经保护、抗肿瘤、抗衰老及生殖作用等方面都有显著疗效。异戊烯基黄酮的化学结构与生物活性之间存在显著的关联性。因此,异戊烯基黄酮的构效关系显得尤为重要,为新化合物的合成及功能预测提供理论依据。Prenylated flavonoids,as a branch of flavone compounds,is characterized by the presence of the prenyl side chain on the skeleton of flavonoids. According to the prenyl binding sites,number and type of constructions,prenylated flavonoids are divided into 3 prenylated flavonoids,5 prenylated flavonoids,6 prenylated flavonoids,8 prenylated flavonoids,multiple side-chain prenylated flavonoids,pyran ring prenylated flavonoids and lavender prenylated flavonoids. Prenylated flavonoids show a wide range of biological activities,particularly with significant efficacy in improving the differentiation of stem cells,anti-inflammatory and immunoregulation and cardiovascular protection,mitigating metabolic diseases and osteoporosis,neural protection,anti-tumor,anti-aging and reproductive function. There is a significant correlation between the chemical structure and biological activity of prenylated flavonoids. Therefore, the structure-activity relationship of prenylated flavonoids is particularly important,and provides a theoretical basis for the synthesis of new compounds and function prediction.

关 键 词：异戊烯基 黄酮 查尔酮 生物活性 构效关系 

分 类 号：R284.1[医药卫生—中药学]