5-取代异唑-3-羧酸酯类化合物的偶极成环制备方法  

Progress on Synthesis of 5-Sbustituted Isoxazole-3-carboxylate Compounds Based Dipole Cyclization

作　　者：靳清贤[1] 张永霞[2] 孙伟[1] 李晶[1] 殷蒙蒙[1] 

机构地区：[1]郑州轻工业学院材料与化学工程学院河南省表界面科学重点实验室,河南郑州450001 [2]河南交通职业技术学院公共基础教学部,河南郑州450005

出　　处：《化学试剂》2015年第9期799-802,826,共5页Chemical Reagents

基　　金：国家自然科学基金资助项目(21401169);郑州轻工业学院博士科研基金资助项目(2013BSJJ020);河南省教育厅科学技术研究重点项目基础研究计划基金资助项目(14B150046)

摘　　要：标题化合物是一类重要的药物中间体,对其合成已有多种制备方法,偶极成环法是一类比较特殊的制备方法,适合特定的异唑类化合物的制备,且具有一定的方法学研究意义。综述了近年来基于偶极成环法合成异唑的研究报道,加以整理分类,并对代表性研究加以总结。Isoxazoles are the important intermediates in drug discovery and development as drug structure fragments. 5-Sbustituted isoxazole-3-carboxylate compounds could be prepared by a variety of synthesis methods,dipole cyclization is a kind of special preparation method,which is suitable for specific isoxazole compounds,and has certain methodological significance. This work reviews the recent research reports based on dipole cyclization of isoxazole. The reported researches were sorted and summed up,the representative research reports were commented.

关 键 词：异唑 偶极成环 合成 

分 类 号：O626[理学—有机化学]