临床药师参与1例硝苯地平与氟康唑联用引起低血压的药学实践  

Clinical pharmacists practice for pharmaceutical care:a case report of hypotension induced by combined use of nifedipine combination withand fluconazole cause hypotension

作　　者：吴晓鹏[1] 李祚勇[2] 李璐[3] 

机构地区：[1]深圳市宝安区松岗人民医院药剂科,深圳518105 [2]赣南医学院第一附属医院药学部,赣州341000 [3]深圳市第二人民医院药学部临床药学科,深圳518035

出　　处：《临床药物治疗杂志》2015年第4期90-92,共3页Clinical Medication Journal

摘　　要：目的:探讨硝苯地平与氟康唑联用引起低血压的发生机制及处理方法,避免类似相互作用再次发生。方法:通过分析临床药师参与的1例高血压合并真菌感染患者经硝苯地平和氟康唑联合治疗后出现低血压,进行用药分析排查。结果:三唑类抗真菌药和钙离子通道阻断剂合用存在药物间的相互作用,可使钙通道拮抗剂的血药浓度升高,导致血压下降。结论:临床药师与医生组成治疗团队,能更好地保障患者的用药安全。Objective： To investigate the cause and treatment of hypotension induced by combined use of nifedipine and fluconazole to avoid the recurrence of similar interactions. Methods： Medication analysis was conducted in one case with hypertension and fungalinfection who had hypotension after combined nifedipine and fluconazole therapy. Results： Combined use of triazole antifungal drugs and calcium channel blockers may cause drug interactions and lead to an increase in plasma concentration of calcium channel antagonists which may cause hypotension. Conclusion： The treating team composed of clinical pharmacists and doctors can better protect the safety of patient medication.

关 键 词：高血压 钙拮抗剂 硝苯地平 氟康唑 相互作用 

分 类 号：R969.3[医药卫生—药理学]