TBAF催化芳环亲核取代反应合成非对称杂芳硫醚  

Synthesis of Unsymmetrical Heteroaryl Thioether by TBAFCatalyzed Aromatic Nucleophilic Substitution Reaction

作　　者：李晓慧[1] 刘全[1] 汪超[1] 刘建平[1] 徐清[1] 

机构地区：[1]温州大学化学与材料工程学院,浙江温州325035

出　　处：《辽宁化工》2015年第8期915-918,921,共5页Liaoning Chemical Industry

摘　　要：四丁基氟化铵(TBAF)可催化苯硫基三甲基硅烷与氯代或溴代杂芳烃的芳环亲核取代(SNAr)反应得到非对称芳杂硫醚。该方法无需过渡金属催化剂,可使用廉价易得的氯代或溴代杂芳烃代替昂贵不易得的氟代杂芳烃,反应在中性条件下进行,官能团兼容性好,是一种较好的合成非对称杂芳硫醚方法。Unsymmetrical heteroaryl thioether was synthesized from phenylthiotrimethylsilane and chloro- or bromo-heteroarene by tetrabutylammonium fluoride （TBAF） catalyzed aromatic nucleophilic substitution （SNAr） reaction. This method does not require transition metal catalysts, can use the relatively inexpensive chloro- or bromo-heteroarenes instead of the more expensive and less available fluoroheteroarenes, and the resction can be performed under milder conditions, so the method is a good method for synthesis of unsymmetrical heteroarvl thioethers.

关 键 词：四丁基氟化铵 苯硫基三甲基硅烷 卤代杂芳烃 芳环亲核取代反应 非对称杂芳硫醚 

分 类 号：TQ028[化学工程]