歼击机飞行员高原驻训前后血清生化指标观察  

Serum biochemical changes in fighter pilots before and after plateau training

作　　者：薛皓晨 朱晓全[2] 薛红[2] 李卫东[2] 徐成轩[2] 

机构地区：[1]第四军医大学,西安710032 [2]空军航空医学研究所载人离心机医学训练基地,北京100089

出　　处：《中华航空航天医学杂志》2015年第1期33-37,共5页Chinese Journal of Aerospace Medicine

摘　　要：目的 评价高原缺氧环境对歼击机飞行员肝功能、肾功能、心肌酶谱、血糖、尿酸和血脂等血清生化指标的影响,为高原航空卫生保障提供依据. 方法 使用全自动生化分析仪,对高原驻训前后35例歼击机飞行员的血清生化指标进行配对t检验. 结果 进驻高原后飞行员空腹血清门冬氨酸氨基转换酶、白蛋白、尿素氮虽有下降（t=2.042、10.329、2.275,P＜0.05或P＜0.01）,但均在正常值范围;直接胆红素、肌酐、β2微球蛋白、乳酸脱氢酶、肌酸激酶和总胆固醇虽明显高于进驻前（t=3.792～12.454,P＜0.01）,但基本位于正常值范围或上限;尿酸明显高于进驻前且高于正常值（t=4.373,P＜0.01）;丙氨酸氨基转换酶、总胆红素、总蛋白、胱抑素C、血糖和甘油三酯水平变化无统计学意义. 结论 高原环境可影响歼击机飞行员部分肝功能、肾功能、心肌酶谱、血糖、尿酸及血脂代谢功能.应采取有效措施积极预防.Objective To evaluate the influence of plateau hypoxia environment on the parameters of liver,renal,cardiac and metabolic functions of fighter pilots,and provide the basis for the high altitude aeromedical service.Methods Serum biochemical indices were examined and compared among 35 fighter pilots before and after 3-month high altitude training by automatic biochemistry analyzer and the results were analyzed by paired t-test.Results Compared with those before plateau training,pilots＇ fasting serum aspartate aminotransferase （AST）,albumin （ALB）,blood urea nitrogen （BUN） levels after plateau training were decreased slightly or significantly （t=2.042,10.329,2.275,P〈0.05 or 〈0.01）,but were still in the normal range.Direct bilirubin （DBIL）,creatinine （Cr）,Beta2-microglobuline （β2-MG）,lactate dehydrogenase （LDH）,creatinine kinase （CK）,total cholesterol （TC） were significantly higher than those before the training （t=3.792-12.454,P〈0.01）,but were basically in the normal range or approaching to upper limits;uric acid （UA） was significantly higher than that before training and the normal （t=4.373,P〈0.01）;alanine aminotransferase （ALT）,total bilirubin （TBIL）,total protein （TP）,cystatin C （Cys C）,glucose （Glu）,triglycerides （TG） levels did not change significantly.Conclusions This study elucidated that high altitude environment can affect pilot＇s partial liver,renal,cardiac and metabolic functions.So the preventive measures should be strengthened.

关 键 词：高海拔 肝功能试验 肾功能试验 尿酸 飞行员 

分 类 号：R85[医药卫生—航空、航天与航海医学]