软体动物模式识别受体研究进展  

Progress of pattern recognition receptors of molluscs

作　　者：高倩[1] 赵琴平[1] 马晓雪[1] 董惠芬[1] 

机构地区：[1]武汉大学基础医学院人体寄生虫学教研室

出　　处：《中国血吸虫病防治杂志》2015年第4期440-443,共4页Chinese Journal of Schistosomiasis Control

基　　金：国家自然科学基金(81401685);湖北省卫生和计划生育委员会血防专项(WJ2015XB008)

摘　　要：软体动物建立了复杂的固有免疫系统以对抗病原生物体的入侵。模式识别受体(Pattern recognition receptors,PRRs)是软体动物启动固有免疫应答的首要分子,其种类甚多,如Toll样受体、C型凝集素及半乳凝素、脂多糖葡聚糖结合蛋白、补体相关分子和肽聚糖识别蛋白等。PRRs具有多种生物学特性,在软体动物的固有免疫中发挥着重要作用。本文对软体动物PRRs的研究进展作一综述。Molluscs have established complete innate immunity to defense against pathogens. The pattern recognition receptors（PRRs）are the sensory receptors of molluscs to resist outside invaders,as the first reactor to initiate the innate immune response. Some PRRs have been identified in several molluscs,including Toll-like receptors（TLRs）,C-type lectins,galectins,lipopolysaccharide-β-1,3-glucan binding protein（LGBP）,C1 q domain-containing protein（C1q DC）,and peptidoglycan recognition protein（PGRP）. PRRs have various biological activities and play important roles in the defense system of molluscs. This paper reviews the research progress of PRRs in molluscs.

关 键 词：软体动物 模式识别受体 固有免疫 Toll样受体 凝集素 半乳凝素 脂多糖葡聚糖结合蛋白 补体相关蛋白 肽聚糖识别蛋白 

分 类 号：Q959.21[生物学—动物学]