低分子肝素联用地塞米松抑制家兔导管相关血栓形成  

Inhibition Effect of Low Molecular Weight Heparin Combined with Dexamethasone on Catheter-related Thrombosis in Rabbit

作　　者：艾熙[1] 陈劲[1] 冯丽娟[2] 官艳[1] 范亚维[1] 阳军[1] 张志伟[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院肝脏外科中心-血管外科,武汉430030 [2]华中科技大学同济医学院附属同济医院PICC组,武汉430030

出　　处：《华中科技大学学报（医学版）》2015年第4期452-454,459,共4页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：湖北省自然科学基金资助项目(No.2012FFB02521);华中科技大学自主创新研究项目(No.01-18-540066)

摘　　要：目的建立稳定的家兔颈静脉导管相关血栓模型,并探讨低分子肝素与地塞米松对其形成的影响。方法将60只日本大耳白兔分为对照组、低分子肝素组、地塞米松组和合用组。将中心静脉导管(CVC)插入右侧颈静脉制造导管相关血栓动物模型。术后分别给予低分子肝素钠/地塞米松。术后第7天观察颈静脉导管相关血栓形成情况及血浆内D-D二聚体水平。结果成功建立简便有效的日本大耳白兔导管相关血栓模型。低分子肝素组及合用组实验兔导管相关血栓形成较对照组显著降低,D-D二聚体水平明显下降(P<0.01)。结论应用低分子肝素能有效预防导管相关血栓。糖皮质激素抗炎治疗可能对预防导管相关血栓形成有一定作用。Objective To investigate the therapeutic effect of low molecular weight heparin sodium and dexamethasone sodium phosphate on catheter-related thrombosis.Methods Sixty Japanese big ear white rabbits were divided into four groups（n=15each）：control group,low molecular weight heparin group,dexamethasone sodium phosphate group,low molecular weight heparin combined with dexamethasone group.A central venous catheter was inserted into right jugular vein to induce catheterrelated thrombosis.After the surgery,control group was treated with normal saline;molecular weight heparin group and dexamethasone sodium phosphate group were subcutaneously injected with low molecular weight heparin and dexamethasone,respectively;low molecular weight heparin combined with dexamethasone group received injection of both.Catheter-related thrombosis in jugular vein and D-Dimer concentration in serum were observed 7days after the surgery.Results Catheter-related thrombosis model was successfully established in Japanese big ear white rabbits.Compared with control group,the formation rates of catheter-related thrombosis in low molecular weight heparin group and low molecular weight heparin combined with dexamethasone group were significantly decreased（P〈0.01）,and the levels of D-dimer were significantly decreased in these groups（P〈0.01）.Conclusion Low molecular weight heparin may prevent catheter-related thrombosis efficiently.Anti-inflammation treatment with glucocorticoid might inhibit catheter-related thrombosis.

关 键 词：导管相关血栓 动物模型 低分子肝素 地塞米松 

分 类 号：R453.9[医药卫生—治疗学]