从“毒损肾络”理论研究糖尿病肾病的发病机制  

The Pathogenesis of Diabetic Nephropathy based on the Theory of "Poison Damage of Renal Collaterals"

作　　者：姜元吉[1] 仉晓露 孙晓红[1] 

机构地区：[1]吉林省延吉市中医医院肾病科,延吉133000

出　　处：《中国中医药现代远程教育》2015年第16期12-13,共2页Chinese Medicine Modern Distance Education of China

摘　　要：糖尿病肾病是由于糖尿病迁延不愈,燥热化毒,毒损肾络而成。其发生和发展是由于持续高血糖引起体内多种蛋白质非酶糖基化及由此形成的晚期糖基化终末产物,而晚期糖基化终末产物间接或直接损伤肾脏微血管,最终导致糖尿病肾病,晚期糖基化终末产物与糖尿病肾病密切相关。依据毒损肾络理论,治疗以益肾通络解毒为法,解毒通络,扶正固本。Diabetic nephropathy is generally induced by chronicle diabetic disease, hot melt poison and poison damage of renal collaterals.Both non enzymatic glycosylation of various proteins induced bysustained hyperglycemia and advanced glycation endproducts（AGEs） resulted from the non enzymatic glycosylation process contribute to the initiation and development of diabetic nephropathy. AGEs can directly or indirectly damage the micro blood vessels in the kidney, resulting in the ultimate diabetic nephropathy. There is high correlation between AGEs and diabetic nephropathy. According to the theory of poison damage of renal collaterals, nourishing kidney and dredging collaterals as well as detoxification can be applied as the major curing method for diabetic nephropathy to detoxificate the body, andstrengthen and consolidate body resistance.

关 键 词：毒损肾络 糖尿病肾病 晚期糖基化终末产物 益肾通络解毒 

分 类 号：R259[医药卫生—中西医结合]