脂肪细胞因子与女性肥胖高血压的相关性研究  

Association between serum leptin, adiponectin, visfatin, obesity and hypertension in female

作　　者：夏昆[1] 丁荣晶[2] 杨渊[2,3] 吴宝恒 张旗[2] 胡大一[2] 

机构地区：[1]首都医科大学附属北京朝阳医院心内科,400016 [2]北京大学人民医院心脏中心,100044 [3] 重庆医科大学附属第一医院心内科,400016 [4] 北京市大兴区魏善庄中心卫生院

出　　处：《中华内科杂志》2015年第9期768-772,共5页Chinese Journal of Internal Medicine

基　　金：高等学校博士学科点专项科研基金资助课题（2109000044）

摘　　要：目的 探讨血脂肪细胞因子瘦素、脂联素、内脂素水平与女性肥胖高血压的关系.方法 206例女性参与者,根据血压和BMI,分成4组：高血压肥胖组（48例）;单纯高血压组（48例）;单纯肥胖组（56例）;正常对照组（54例）.测定各组血清瘦素、脂联素和内脂素水平,分析其与血压、BMI和腰围的相关性.结果 瘦素水平在非肥胖组[单纯高血压组（4.47 ±1.26） ng/L;正常对照组（3.73 ±1.18）ng/L]显著高于肥胖组[高血压肥胖组（2.97 ±1.46） ng/L;单纯肥胖组（3.02±1.18） ng/L],在血压≥140/90 mmHg（1mmHg =0.133 kPa）组显著高于血压＜140/90 mmHg组;脂联素水平在正常对照组[38.99 （19.75,103.71） μg/L]显著高于肥胖高血压组、单纯高血压组和单纯肥胖组,后3组间差异无统计学意义;无论有无肥胖,内脂素水平在高血压组[高血压肥胖组：3.84（3.40,5.35） ng/L;单纯高血压组：3.75 （1.63,6.67） ng/L]明显高于非高血压组[单纯肥胖组：3.19 （0.96,9.45） ng/L;正常对照组：3.23（1.92,4.64） ng/L].Logistics回归分析显示,肥胖者脂联素每降低1μg/L,高血压患病风险增加1.6％,腰围每增加1 cm,高血压患病风险增加8.3％;内脂素每增加1 ng/L,高血压患病风险增加5.45％ （P＜ 0.05）,与瘦素无相关.结论 脂联素、内脂素与女性血压和肥胖均相关,可能参与女性肥胖高血压的发生.Objective This study was aimed to investigate the relationship between serum leptin,adiponectin,visfatin levels and obesity and essential hypertension in female subjects.Methods According to BMI and blood pressure,206 female participants enrolled were divided into four groups：group 1：obesity and hypertension （48 cases）;group 2：non-obesity but hypertension （48 cases）;group 3：obesity and normotension （56 cases） and group 4：normal BMI and blood pressure （54 cases）.Serum leptin,adiponectin and visfatin levels were detected and their relationships to BMI,blood pressure and waist circumference were analysed.Results Serum leptin levels were significantly higher in non-obese groups [group 2：（4.47 ±1.26） ng/L,group 4：（3.73-±1.18）ng/L] than in obese groups [group 1：（2.97 ± 1.46） ng/L,group 3：（3.02 ± 1.18） ng/L],and higher in hypertension groups than in normotension groups.Serum adiponectin levels were obviously higher in group 4 [38.99 （19.75,103.71） μg/L] than in the other three groups.There were no significant differences in adiponectin levels among group 1,2 and 3.Serum levels of visfatin were lower in normotension groups [group 3：3.19 （0.96,9.45） ng/L;group 4：3.23 （1.92,4.64） ng/L] than in hypertension groups [group 1：3.84 （3.40,5.35） ng/L;group 2：3.75 （1.63,6.67） ng/L] irrespective of obesity.Logistics regression analysis showed that there was 1.6%,8.3%,or 5.45% increased risk for hypertension for each 1 μg/L decrease in adiponectin,1 cm increase in waist circumference,or 1 μg/L increase in visfatin level in obesity,respectively.No relationship could be viewed between leptin and hypertension.Conclusions Adiponectin and visfatin levels were correlated with obesity and blood pressure in females.Both adipokines may play a crucial role in the development of hypertension in female obesity.

关 键 词：瘦素 脂联素 内脂素 高血压 肥胖症 女性 

分 类 号：R589.2[医药卫生—内分泌] R544.1[医药卫生—内科学]