A method for assessing nanomaterial dispersion quality based on principal component analysis of particle size distribution data  

作　　者：R.Tantra C.Oksel K.N.Robinson A.Sikora X.Z.Wang T.A.Wilkins 

机构地区：[1]National Physical Laboratory [2]Institute of Particle Science and Engineering,School of Chemical and Process Engineering,University of Leeds

出　　处：《Particuology》2015年第5期30-38,共9页颗粒学报（英文版）

基　　金：Framework 7 Projects(MARINA and NanoReg);DEFRA for providing funding for this study

摘　　要：Seemingly contradictory findings between studies are a major issue in nanoecotoxicological research and have been explained as a result of the lack of comparability between assay methods, with dispersion of nanomaterials being identified as a key factor. Here we show the use of a multivariate method, principal component analysis （PCA）, as a tool in protocol development and categorization of dispersion quality. Results show the significance of particle concentration within a protocol, and its effect on repeatability. Our results suggest that future studies should involve the use of PCA as a powerful data exploration tool to facilitate method development, comparability and integration of data across different laboratories.Seemingly contradictory findings between studies are a major issue in nanoecotoxicological research and have been explained as a result of the lack of comparability between assay methods, with dispersion of nanomaterials being identified as a key factor. Here we show the use of a multivariate method, principal component analysis （PCA）, as a tool in protocol development and categorization of dispersion quality. Results show the significance of particle concentration within a protocol, and its effect on repeatability. Our results suggest that future studies should involve the use of PCA as a powerful data exploration tool to facilitate method development, comparability and integration of data across different laboratories.

关 键 词：Nanomaterial characterization Principal component analysis NANOTOXICOLOGY DISPERSION Particle size distribution 

分 类 号：TB383.1[一般工业技术—材料科学与工程]