转录因子7类似物2基因多态性与新疆维吾尔族人群2型糖尿病遗传易感性的关系  

Relationship between genetic polymorphism of transcription factor 7-like 2 and genetic susceptibility to type 2 diabetes mellitus in Uygur population of Xinjiang region

作　　者：王志强[1] 马琦[2] 王婷婷[1] 苏银霞[1] 马艳[1] 朱筠[2] 姚华[2] 

机构地区：[1]新疆医科大学公共卫生学院,新疆乌鲁木齐830011 [2]新疆医科大学第一附属医院代谢性疾病重点实验室,新疆乌鲁木齐830054

出　　处：《基础医学与临床》2015年第9期1162-1166,共5页Basic and Clinical Medicine

基　　金：国家重点基础研究发展计划(973计划)(2012CB722403)

摘　　要：目的探讨新疆地区维吾尔族人群转录因子7类似物2(TCF7L2)基因多态性与2型糖尿病的关系。方法采用病例-对照研究设计,以经确诊的819例2型糖尿病患者作为病例组,选取731例健康个体作为对照组。收集研究对象血液标本5m L,提取基因组DNA。应用基质辅助激光解吸附电离飞行时间质谱分析质谱技术(MALDI-TOF)进行多态性检测,用logistic回归计算OR(95%CI)值,比较不同基因型与2型糖尿病患病风险的关系。结果病例组TCF7L2基因rs7901695位点的TC和CC基因型频率,C等位基因频率显著高于对照组(P<0.05)。未发现TCF7L2基因与环境因素的交互作用与2型糖尿病相关联。结论 TCF7L2基因rs7901695多态性位点可能与新疆维吾尔族人群2型糖尿病具有相关性,而rs7085532多态性位点可能与新疆维吾尔族人群2型糖尿病无相关性。Objective To identify the potential association of transcription factor 7-like 2 （ TCF7L2 polymorphisms with type 2 diabetes mellitus in Uygur population of Xinjiang region. Methods In this case-control study,819 ca- ses of type 2 diabetes mellitus patients were recruited in case group and 731 healthy individuals were selected as control. 5 mL of blood sample were collected from each subject. The polymorphism was examined by matrix-assis- ted laser desorption/ionization-time of flight （MALDI-TOF） and the OR value （95% CI） was evaluated by Logistic Regression Method to analyze the relationship between susceptibility to type 2 diabetes mellitus and different geno- types. Results In case group, the frequencies of TC, CC genotype and C allele at rs7901695 were higher than the corresponding frequencies in control group （P 〈 0. 05）. The interaction between TCF7L2 and environment risk factors did not contribute to the occurrence of the type 2 diabetes mellitus. Conclusions The polymorphisms of rs7091695 in TCFTL2 but not rs7085532 in TCG7L2 may be associated with type 2 diabetes mellitus in Uygur pop-ulation in Xinjiang region.

关 键 词：多态性 TCF7L2基因 2型糖尿病 维吾尔族 

分 类 号：R587.1[医药卫生—内分泌]