黑龙江省健康青少年血清钙、磷、碱性磷酸酶的参考范围  

Reference intervals of serum calcium,phosphate and alkaline phosphatase of healthy school children and adolescents in Heilongjiang province

作　　者：程歆琦[1] 程倩[1] 邱玲[1] 刘荔[1] 刘茜[1] 韩少梅[2] 朱广瑾 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院检验科,北京100730 [2]中国医学科学院基础医学研究所流行病统计学系,北京100005 [3]生理学与病理生理学系,北京100005

出　　处：《基础医学与临床》2015年第9期1205-1208,共4页Basic and Clinical Medicine

基　　金：科技部科技基础性工作专项(2006FY110300)

摘　　要：目的调查分析黑龙江省健康青少年血清钙、磷和碱性磷酸酶水平,建立性别和年龄相关的参考范围。方法于2008年7月-2009年6月,从黑龙江省哈尔滨和牡丹江的市区、郊区随机抽取2 101名9~18岁健康中小学生进行体检,测定血清钙、磷和碱性磷酸酶浓度。筛除离群数据个体后,共2 091名受试者入选。考虑性别和年龄因素,建立相应的血清钙、磷和碱性磷酸酶的参考范围（P2.5~P97.5）。结果描述了9~18岁青少年男性和女性血清钙、磷和碱性磷酸酶水平随年龄、性别的变化趋势。血清钙、磷和碱性磷酸酶水平与年龄呈明显的负相关,且男性高于女性（P〈0.001）。全部人群的血清钙、磷和女性的碱性磷酸酶水平随年龄的增加而下降,而男性的13岁年龄组碱性磷酸酶水平最高,13岁前随年龄增加而增加,13岁后随年龄增加而降低。结论初步建立了黑龙江省健康青少年血清钙、磷和碱性磷酸酶的参考范围,对临床医生特别是儿科医生对上述指标的结果解释和临床干预具有很好的参考价值。Objective To analyze the serum calcium, phosphate and alkaline phosphatase level among apparently healthy school children and adolescents in Heilongjiang Province and establish the reference intervals in different gender and different age groups. Methods Random sample of 2 101 primary and secondary school students from 9 to 18-year-old was collected from different district of Heilongjiang Province including Harbin and Mudanjiang from July 2008 to June 2009. The fasting venous blood was collected and serum calcium, phosphate and alkaline phos- phatase concentration was measured as soon as possible. After screening outlier individual, a total of 2 091 subjects were enrolled. The reference intervals of serum calcium, phosphate and alkaline phosphatase for healthy school children and adolescents were established by gender and age （ P2.5 to P97.5 ）. Results The change tendency of serum calcium, phosphate and alkaline phosphatase with age and sex were presented. All these parameters had shown inverse relationship with age and were significantly higher in boys than girls （P 〈 0. 001 ）. Serum calcium, phosphate of both sexes and serum alkaline phosphatase of girls declined progressively with age. However, the highest alkaline phosphatase level was seen at 13 years in boys. Alkaline phosphatase showed a positive correlation with age before 13 years of age, but after that alkaline phosphatase started to decline. Conclusions Reference in- tervals of serum calcium, phosphate and alkaline phosphatase for healthy school children and adolescents in Hei- longjiang Province in the age group of 9 -18 years were presented, which supply good reference value for clinicians especially pediatricians to interpret the results of school children and adolescents and make decision.

关 键 词：健康青少年 钙 磷 碱性磷酸酶 参考范围 

分 类 号：R446.1[医药卫生—诊断学]