利用散射光声微分成像技术实现弱吸收物质显微成像  

Scattering Photoacoustic Differential Microscopy of Weak Absorbing Material

作　　者：黄敏芳[1] 唐志列[1,2,3] 吴泳波[1,2,3] 

机构地区：[1]华南师范大学物理与电信工程学院,广东广州510006 [2]广东省量子调控工程与材料重点实验室,广东广州510006 [3]广东省光电检测仪器工程技术研究中心,广东广州510006

出　　处：《激光生物学报》2015年第3期232-236,共5页Acta Laser Biology Sinica

基　　金：国家自然科学基金(61178086);广东省自然科学基金重点项目(S2013020012810)

摘　　要：光声显微成像技术依赖于样品的内源性光吸收,对强散射弱吸收样品成像效果差,甚至无法进行成像。为了实现强散射弱吸收高透明生物样品的光声显微成像,以及获得图像的边缘增强效果,使光声显微成像技术在实际的生物医学研究中更有应用价值,本文首次将散射光声技术引入到光声微分显微技术中,研制了新型的散射光声微分成像技术。该技术不仅可以获得强散射弱吸收高透明生物样品的散射光声显微图像,还可以获得对应的边缘清晰的散射光声微分图像,对在生物医学研究领域有重要的应用意义。Depending on endogenous optical absorption of sample,photoacoustic microscopy for the strong scattering weak absorbing sample is difficult. In order to realize the photoacoustic microscopy of strong scattering weak absorbing biological sample,and obtain the edge enhancement image,which make the photoacoustic microscopy technique has meaningful application value in biomedical research,this paper firstly combine the scattering photoacoustic technique with the photoacoustic differential microscopy and develop a novel scattering photoacoustic differential imaging technique.This technique can not only obtain scattering photoacoustic microscopic images of strong scattering weak absorbing biological sample,but also obtain the corresponding scattering photoacoustic differential images with clear edge. This tech-nique has important application significance in the field of biomedical research.

关 键 词：光声显微术 边缘增强 散射光声技术 空间微分技术 

分 类 号：O438[机械工程—光学工程]