三种药物联合异丙酚镇痛镇静对ICU内机械通气患者的疗效对比  

A Comparison of the Sedative Effects of Three Drugs Combined with Propofol for Mechanically Ventilated Patients in ICU

作　　者：杜志安[1] 胡占升[1] 孙美娜[1] 

机构地区：[1]辽宁医学院附属第一医院重症医学科,辽宁锦州121001

出　　处：《医学与哲学（B）》2015年第8期27-29,42,共4页Medicine & Philosophy(B)

摘　　要：探讨酒石酸布托啡诺、氟比洛芬酯、芬太尼与异丙酚联合对重症加强治疗病房(ICU)机械通气患者的镇痛镇静效果。将90例术后机械通气患者随机分为布托啡诺组、氟比洛芬酯组、芬太尼组,各30例。3组患者应用异丙酚达到目标镇静状态。观察用药后不同时间点HR、MAP、RR及FPS评分变化;记录异丙酚用量、机械通气及ICU滞留时间、不良反应。结果布托啡诺组给药后患者HR、MAP、RR、FPS评分、异丙酚用量、机械通气及ICU滞留时间及不良反应发生率明显降低(P<0.05)。因此应用布托啡诺镇痛起效快,可减少镇静药物用量、机械通气及ICU治疗时间,降低不良反应发生率。Discussion the effection of butorphanol tartrate, flurbiprofen axetil, fentanyl associating with propofol sedate patients with mechanical ventilation in the intensive care unit （ICU）. Choose 90 cases of mechanically ventilated patients in ICU which were randomly divided into three groups butorphanoi, flurbiprofen axetil, fentanyl and each group with 30 cases. 3 groups of patients were used propofol until it reached the target sedation. Observe the index for the 3 groups during different time periods which including HR, MAP, RR and the FPS rate. Recording the dose of propofol, the duration of mechanical ventilation, the treatment time in ICU and adverse events. After treatment, patients＂ HR, MAP, RR, FPS, the dose of propofol, duration of mechanical ventilation and residence time in ICU and adverse events in butorphanol group are decreased obviously （P〈0. 05）. The patients using butorphanol tartrate rapid onset of analgesic, shortening the dose of sedative drugs, mechanical ventilation and the treatment time in ICU of patients, also reducing the incidence of adverse reactions.

关 键 词：重症加强治疗病房 布托啡诺 芬太尼 氟比洛芬酯 镇痛镇静 

分 类 号：R605[医药卫生—外科学]