2011-2013年患者呼吸道感染铜绿假单胞菌耐药监测分析  

Surveillance of drug resistance of Pseudomonas aeruginosa causing respiratory tract infections in 2011-2013

作　　者：顾国忠[1,2] 杨利[1,2] 白艳玲[1,2] 马权[1,2] 董晓丰[1,2] 

机构地区：[1]大庆油田总医院 [2]大庆市第一医院呼吸科,黑龙江大庆163001

出　　处：《中华医院感染学杂志》2015年第17期3861-3863,共3页Chinese Journal of Nosocomiology

基　　金：黑龙江科技厅研究基金资助项目(201207857)

摘　　要：目的了解大庆地区患者呼吸道感染铜绿假单胞菌对临床常用抗菌药物的耐药性,为临床合理用药提供依据。方法比较2011-2013年呼吸道感染患者分离的1 623株铜绿假单胞菌对临床常用抗菌药物耐药性,使用法国生物梅里埃公司VITEK-2全自动细菌鉴定及药敏分析仪进行菌种鉴定,药敏试验采用手工测定法。结果2011年共分离铜绿假单胞菌496株,铜绿假单胞菌对阿米卡星敏感性最高,敏感率为78.48%,其次为美罗培南,敏感率为77.61%;2012年分离出铜绿假单胞菌496株,铜绿假单胞菌对阿米卡星敏感性仍最高,敏感率为92.03%,其次为妥布霉素,敏感率为91.58%;2013年分离出铜绿假单胞菌631株,铜绿假单胞菌对阿米卡星敏感性仍最高,敏感率为86.42%,其次为环丙沙星,敏感率为76.72%。结论铜绿假单胞菌对常用抗菌药物较敏感,传统敏感药物亚胺培南、头孢吡肟及头孢他啶敏感率呈逐年下降趋势,但仍保持约60.00%的敏感性,而阿米卡星及环丙沙星仍保持较高敏感性,可供临床选择。OBJECTIVE To investigate the drug resistance of the Pseudomonas aeruginosa causing respiratory tract infections to the commonly used antibiotics in Daqing so as to provide guidance for reasonable clinical use of antibiotics.METHODS A total of 1 623 strains of P.aeruginosa were isolated from 2011 to 2013,the drug resistance rates of the strains to the commonly used antibiotics were observed and compared,the bacterial identification was carried out by using VITEK-2automatic bacterial identification and drug susceptibility analyzer of BioMerieux,France,and the drug susceptibility testing was performed with the use of manual determination.RESULTS Totally496 strains of P.aeruginosa were isolated in 2011,and the drug susceptibility rate of the P.aeruginosastrains to amikacin was the highest（78.48%）,followed by the drug susceptibility rate to meropenem（77.61%）;totally496strains of P.aeruginosa were isolated in 2012,and the drug susceptibility rate of the P.aeruginosastrains to amikacin remained the highest（92.03%）,followed by the drug susceptibility rate to tobramycin（91.58%）;totally 631 strains of P.aeruginosa were isolated in 2013,and the drug susceptibility rate of the P.aeruginosa strains to amikacin remained the highest（86.42%）,followed by the drug susceptibility rate to ciprofloxacin（76.72%）.CONCLUSIONThe P.aeruginosastrains are highly susceptible to the commonly used antibiotics,the drug susceptibility rates to the conventional antibiotics including imipenem,cefepime,and ceftazidime are decreased year by year but remained around 60.00%;however,the strains remain highly susceptible to amikacin and ciprofloxacin,which are preferable for clinical treatment.

关 键 词：铜绿假单胞菌 耐药性 呼吸道 

分 类 号：R378.991[医药卫生—病原生物学]