肺癌患者真菌感染的临床调查分析  

Clinical investigation of fungal infections in lung cancer patients

作　　者：杨勋[1] 赵苏[1] 陈贝贝[1] 张积人 

机构地区：[1]武汉市中心医院呼吸内科,湖北武汉430014 [2]南方医科大学珠江医院,广东广州510280

出　　处：《中华医院感染学杂志》2015年第17期3963-3964,3975,共3页Chinese Journal of Nosocomiology

基　　金：卫生部科技发展中心基金资助项目(W2009BX001)

摘　　要：目的了解医院肺癌住院患者真菌感染的状况,分析相关的危险因素,为控制肺癌患者的真菌感染提供理论依据。方法回顾性调查分析医院肿瘤科2010年1月-2013年12月857例肺癌患者的临床资料;计算每年真菌感染率及平均感染率,对肺癌住院患者发生真菌感染的相关因素进行分析;采用Excel2007对数据进行整理,SPSS17.0进行数据分析。结果 857例肺癌患者中发生真菌感染135例,感染率为15.8%;2010-2013年肺癌患者感染率分别为13.2%、15.4%、16.4%和17.5%,呈逐年上升趋势;年龄≥65岁、有吸烟史、有基础疾病、肺癌中晚期、住院时间≥14d、有侵入性操作、预防性使用抗菌药物、进行放(化)疗治疗、手术治疗是肺癌患者真菌感染的相关影响因素(P<0.05)。结论肺癌住院患者真菌感染率较高,且呈逐年上升趋势,肺癌患者发生真菌感染的危险因素较为复杂,建议从积极治疗基础疾病、严格控制各种侵入性检查、避免预防性使用抗菌药物、早期治疗缩短住院时间等方面进行预防和控制,降低真菌感染率。OBJECTIVE To investigate the prevalence of fungal infections in the hospitalized lung cancer patients and analyze the related risk factors so as to provide theoretical basis for control of the fungal infections in the lung cancer patients.METHODS The clinical data of 857 lung cancer patients who were treated in the department of oncology from Jan 2010 to Dec 2013 were retrospectively analyzed.The incidence of fungal infections in each year and the average infection rate was calculated,the related factors for the fungal infections in the hospitalized lung cancer patients were observed,the data were processed by using Excel 2007,and the statistical analysis was performed with the use of SPSS 17.0software.RESULTS The fungal infections occurred in 135 of 857lung cancer patients,with the infection rate of 15.8%.The incidence of fungal infections was 13.2%in 2010,15.4%in 2011,16.4%in 2012,and 17.5%in 2013,showing an upward trend.The related influencing factors for the fungal infections in the lung cancer patients included the no less than 65 years of age,history of smoking,underlying disease,middle and advanced lung cancer,length of hospital stay no less than 14 days,invasive operation,prophylactic use of antibiotics,chemoradiotherapy,and surgical treatment（P〈0.05）.CONCLUSIONThe incidence of fungal infections is relatively high in the hospitalized lung cancer patients and shows an upward trend.The risk factors for the fungal infections in the lung cancer patients are complex.It is suggested that the prevention and control of the fungal infections should be carried out through the active treatment of underlying diseases,strict control of invasive examinations,avoiding antibiotics prophylaxis,and shortening the length of hospital stay for early treatment.

关 键 词：肺癌 真菌 医院感染 

分 类 号：R181.32[医药卫生—流行病学]