碳酸氢钠液含漱预防放疗患者口腔真菌感染的效果研究  

Effect of sodium bicarbonate brine gargle on prevention of oral fungal infections in patients undergoing radiotherapy

作　　者：曾晓燕[1] 周维[2] 张波[1] 

机构地区：[1]湖北民族学院附属民大医院口腔科,湖北恩施445000 [2]湖北民族学院附属民大医院检验科,湖北恩施445000

出　　处：《中华医院感染学杂志》2015年第17期4025-4027,共3页Chinese Journal of Nosocomiology

基　　金：湖北省科技厅研究基金资助项目(05624-08)

摘　　要：目的调查碳酸氢钠液含漱对化疗患者口腔真菌感染的预防作用,为临床应用提供指导。方法选取医院收治的放疗患者120例,将其分为试验组和对照组,各60例,对照组仅接受常规预防性治疗,试验组在对照组治疗的基础上采用碳酸氢钠液定期进行含漱,测量两组患者口腔pH值并对比观察两组患者口腔真菌感染情况。结果治疗前试验组及对照组患者口腔pH值均偏酸性,差异无统计学意义;治疗后,试验组患者口腔pH值上升明显,高于对照组,差异有统计学意义(P<0.05);对照组口腔黏膜白斑发生率为15.0%、试验组为1.7%,两组比较差异有统计学意义(P<0.05);对照组口腔黏膜溃疡发生率为13.3%、试验组为5.0%,两组比较差异无统计学意义;对照组口腔真菌感染发生率为21.7%、试验组为5.0%,两组比较差异有统计学意义(P<0.05)。结论放疗患者使用碳酸氢钠液定期进行含漱可在一定程度上降低口腔真菌感染率,起到预防作用,该方法经济、实用,便于操作且无不良反应。OBJECTIVE To investigate the effect of sodium bicarbonate brine gargle on prevention of oral fungal infections in patients undergoing chemotherapy so as to provide guidance for clinical application.METHODS A total of 120 patients who underwent the chemotherapy in the hospital were enrolled in the study and divided into the experimental group and the control group,with 60 cases in each.The control group only received the conventional preventive treatment,and the experimental group received the regular mouthwash with sodium bicarbonate brine gargle on the basis of the treatment of the control group.The oral pH values of the two groups of patients were determined,and the incidence of oral fungal infections was observed and compared between the two groups.RESULTS The oral pH value of the experimental group and the control group was slightly acidic before the treatment,and there was no significant difference;the oral pH value of the experimental group was higher than that of the control group after the treatment,with significant difference（P〈0.05）.The incidence of oral leukoplakia was15.0%in the control group,1.7% in the experimental group,and there was significant difference between the two groups（P〈0.05）.The incidence of oral ulcers was 13.3%in the control group,5.0%in the experimental group,and there was no significant difference between the two groups.The incidence of oral fungal infections was21.7% in the control group,5.0% in the experimental group,with significant difference（P〈0.05）.CONCLUSIONThe regular gargle with sodium bicarbonate brine,to a certain degree,can reduce the incidence of oral fungal infections in the patients undergoing radiotherapy,showing a role of prevention,and it is economical,practical,and easy to operate,without adverse reactions to be induced.

关 键 词：碳酸氢盐水 放疗 口腔感染 预防 

分 类 号：R181.32[医药卫生—流行病学]