2型糖尿病患者血清β-抑制蛋白2与代谢指标的相关性分析  

Relationship between serumβ-arrestin 2 and metabolic indices in patients with type 2 diabetes mellitus

作　　者：杨华[1] 杨晓东[1] 饶丽华[1] 刘云涛[2] 

机构地区：[1]三峡大学仁和医院检验科,宜昌443001 [2]三峡大学仁和医院内分泌科,宜昌443001

出　　处：《中国糖尿病杂志》2015年第9期819-821,共3页Chinese Journal of Diabetes

摘　　要：目的探讨不同BMI的T2DM患者血清β-抑制蛋白2水平变化及与代谢指标的相关性。方法 170例T2DM患者分为体重正常(Con)组55例、超重(Ow)组57例及肥胖(Ob)组58例,测定各组相关指标并行统计学分析。结果血清β-抑制蛋白2水平在Con、Ow及Ob组分别为(331.31±11.59)vs(321.18±17.47)vs(303.95±13.63)ng/L,组间两两比较,差异有统计学意义(P<0.05)。相关分析结果显示,β-抑制蛋白2水平与BMI、TG、FIns、胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)呈负相关(r分别为-0.404、-0.328、-0.353、-0.308、-0.260,P<0.01);多元逐步回归分析显示,BMI与β-抑制蛋白2水平独立相关,但未发现β-抑制蛋白2与TG、FIns、HOMA-IR及HOMA-β的相关性。结论 T2DM患者中,BMI是影响血清β-抑制蛋白2水平降低的独立危险因素。Objective To investigate the levels of serumβ-arrestin 2in type 2diabetic（T2DM）patients with different body mass index（BMI）and to analyze the association of serumβ-arrestin 2with metabolic indices. Methods A total of 170T2 DM patients were enrolled and divided into three groups according to BMI as normal weight group（Con,n=55）,over-weight group（Ow,n=57）and obese group（Ob,n=58）.Several related indices including blood chemistry values were determined and analyzed statistically. Results（1）Serumβ-arrestin 2levels in Con group,Ow group and Ob group were（331.31±11.59）,（321.18±17.47）and（303.95±13.63）ng/L respectively and the differences of pairwise comparison among three groups were statistically significant（P〈0.05）.（2）Serumβ-arrestin 2levels were negatively correlated with BMI,TG,FIns,HOMA-IR and HOMA-β（r=-0.404,-0.328,-0.353,-0.308,-0.260,P〈0.01）.Multiple stepwise regression analysis showed that BMI was independently associated with serumβ-arrestin 2.TG,FIns,HOMA-IR and HOMA-βhad no association with the levels of serumβ-arrestin 2. Conclusion BMI is an independent risk factor for decreased levels of serumβ-arrestin 2in T2 DM patients.

关 键 词：β-抑制蛋白2 糖尿病 2型 体重指数 

分 类 号：R587.1[医药卫生—内分泌]