激活转录因子4与糖脂代谢相关性的研究进展  

Research progress of activating transcription factor 4 in glucose and lipid metabolism

作　　者：张璞[1] 任路平[2] 宋光耀[2] 

机构地区：[1]河北医科大学研究生学院,050017 [2]河北医科大学内科学教研室

出　　处：《中国糖尿病杂志》2015年第9期856-858,共3页Chinese Journal of Diabetes

基　　金：国家自然科学基金青年科学基金项目(81200639)

摘　　要：激活转录因子4(ATF4)是一种碱性亮氨酸拉链转录因子,参与多种生理代谢过程,如应激、炎症及肿瘤生长。研究表明,ATF4可调节糖脂代谢、胰岛素分泌及敏感性。ATF4调节代谢可能与内质网应激(ERS)、过氧化物酶体增生物激活的受体1α(PGC1α)及雷帕霉素标靶(TOR)通路相关。本文就ATF4调节糖脂代谢研究进展作一综述。Activating transcription factor 4（ATF4）is an alkaline leucine zipper transcriptional factor,which is involved in many physiological metabolism processes such as stress response,inflammation and tumor growth.Moreover,recent studies have shown that ATF4 also plays a key role in regulating lipid and glucose metabolism,insulin secretion and insulin sensitivity,which may related to pathways such as endoplasmic reticulum stress（ERS）,peroxisome proliferator-activated receptor gamma coactivator（PGC1α）and target of rapamycin（TOR）.This article summarized the recent research progress of ATF4 in regulating glucose and lipid metabolism.

关 键 词：激活转录因子4 脂代谢 糖代谢 

分 类 号：R33[医药卫生—人体生理学]