2-丙基-4-戊烯酸血药浓度与谷丙转氨酶的关系  

Correlation Analysis of Valproic Acid's Metabolites 2-propyl-4-pentenoic in Plasma and Liver Function of Patients

作　　者：吴斯[1] 谢娟[1] 李龙宽 

机构地区：[1]贵州医科大学附属人民医院,贵州贵阳550002 [2]贵州医科大学第三附属医院,贵州都匀558000

出　　处：《贵阳医学院学报》2015年第10期1047-1050,共4页Journal of Guiyang Medical College

基　　金：贵州省卫生厅基金(项目编号:gzwkj2010-1-003)

摘　　要：目的：研究癫痫儿童血液中丙戊酸毒性代谢产物2-丙基-4-戊烯酸（4-ene-VPA）血药浓度与谷丙转氨酶（ALT）的关系。方法：选取96例癫痫儿童作为研究对象,采用反向高效液相色谱法（RP-HLPC）法测定患儿血浆中4-ene-VPA的血药浓度,采用常规生化检测法检测患儿静脉血中ALT的含量,并进行相关性分析。结果：0~≤2岁组癫痫患儿血浆中4-ene-VPA血药浓度与ALT正相关（P=0.018,r=0.621）关系。结论：对于0~≤2岁癫痫患儿,服用丙戊酸时应重点监测肝功能。Objective： To explore the correlation between plasma concentration of sodium valproate＇s metabolites 2-propyl-4-pentenoic and ALT. Methods： A total of 96 cases of epileptic children patients who took sodium valproate medicine over 7 days and reached steady drug concentration in plasma were enrolled in this study. RP-HLPC was adopted to determine the blood concentration of 2-propyl-4-pente- noic. The ALT content in venous blood of patients was determined by conventional biochemical detec- tion method. The correlation analysis between the blood concentration of 2-propyl-4-pentenoic and ALT content in venous blood was conducted by SPSS19.0. Results： The blood concentration of 2-propyl-4- pentenoic was positively correlated to ALT content in venous blood in 0 - ≤2 years old patients （ P = 0.018, r =0.621 ）, but there was no significant correlation between the level of 4-ene-VPA and ALT in other age group. Conclusion： For 0 - ≤2 years old epileptic children patients who took sodium val- proate, liver function should be monitored emphatically.

关 键 词：丙戊酸 2-丙基-4-戊烯酸 反向高效液相色谱法 丙戊酸的代谢产物 血药浓度 

分 类 号：R917[医药卫生—药物分析学] R969.3[医药卫生—药学]