γ干扰素释放试验在肺结核早期诊断中的应用价值  

Application Value of IFN-γ Release Assay in the Early Diagnosis of Tuberculosis

作　　者：王君兰[1] 高航[1] 刘楠[1] 李凯[1] 包勇[1] 

机构地区：[1]成都市第三人民医院呼吸内科,四川成都610031

出　　处：《黑龙江医学》2015年第8期908-909,共2页Heilongjiang Medical Journal

摘　　要：目的探讨分析γ干扰素释放试验在肺结核早期诊断中的应用价值。方法选取2012-10～2014-06间在我院初诊为肺结核的患者72例,将其列为观察组,并选取同期来我院健康体检者40例,将其列为对照组,均行γ干扰素释放试验和结核菌素试验。结果根据γ干扰素释放试验结果,观察组患者治疗前阳性率为86.1%,明显高于治疗后的6.9%,P〈0.05;通过与影像及组织病理检查结果比较,γ干扰素释放试验的肺结核早期诊断灵敏度为92.3%（60/65）,特异度为71.4%（5/7）,阳性预测值为95.8%（60/62）,阴性预测值为50.0%（5/10）。结论γ干扰素释放试验对肺结核的早期诊断具有较高的灵敏度和特异度,具有较高的临床应用价值。Objective To analyze the value of IFN- γ release assay in the early diagnosis of tuberculosis. Methods 72 newly diagnosed TB patients were selected in the hospital from October,2012 to June,2014 as observation group,and 40 healthy cases in the hospital in the same period as the control group,doing interferon- γ release assays and tuberculin skin test. Results According to the test results of IFN- γ release,observation patients positive rate before treatment was 86. 1%,which was significantly higher than 6. 9% after treatment,P〈0. 05; By comparison with imaging and histopathological findings,γ- interferon release early diagnosis of tuberculosis test sensitivity was 92. 3%（ 60 /65）,specificity was 71. 4%（ 5 /7）,positive predictive value was 95. 8%（ 60 /62）,and negative predictive value was 50. 0%（ 5 /10）. Conclusion IFN- γ release assays for the early diagnosis of tuberculosis has a high sensitivity and specificity,with great clinical value.

关 键 词：Γ干扰素释放试验 肺结核 早期诊断 

分 类 号：R521[医药卫生—内科学]