不同浓度脊髓康对脊髓损伤大鼠诱发电位的影响  

Effects of different dose Jisuikang on spinal cord- evoked potentials after spinal cord injury in rats

作　　者：尹恒[1,2] 杨俊锋[1,2] 马勇[1] 范竞 张亚峰[2] 张婕[2] 王建伟[2] 

机构地区：[1]南京中医药大学,南京210023 [2]无锡市中医医院骨伤科,江苏无锡214000 [3]南京中医药大学附属医院骨伤科,南京210029

出　　处：《中国临床药理学杂志》2015年第17期1773-1776,共4页The Chinese Journal of Clinical Pharmacology

基　　金：江苏省自然科学基金面上基金资助项目(BK2011180)

摘　　要：目的观察不同浓度脊髓康对脊髓损伤大鼠诱发电位的影响。方法 SD大鼠60只,按体重随机分为6组,假手术组、模型组、对照组(强的松,0.06 g·kg-1·d-1)、高中低3个剂量(脊髓康,50,25,12.5 g·kg-1·d-1)实验组。分别于术前和术后即刻及术后3,7,14,28 d对大鼠进行体感诱发电位(SEP)与运动诱发电位(MEP)检测,观察潜伏期与波幅的变化。结果中剂量实验组对SEP潜伏期及波幅的改善优于高、低2个剂量实验组,但与对照组比较无明显差异。中剂量实验组对于MEP潜伏期缩短与对照组接近,优于高、低2个剂量实验组,对于波幅的提高优于其他给药组。结论中剂量脊髓康对于脊髓损伤后神经功能恢复具有良好疗效。Objective To observe the effects of different concentrations Jisuikang on spinal cord- evoked potentials after spinal cord injury in rats. Methods Sixty SD rats were divided into 6 groups randomly,sham group,model group,control group（ prednisone,0. 06 g · kg- 1·d- 1）,the high- dose,mid- dose, low- dose（ Jisuikang,50,25,12. 5g·kg- 1·d- 1） test groups. The sensory evoked potentials（ SEP） and motor evoked potentials（ MEP） were tested at preoperative and postoperative 0,3,7,14,28 d. Then the changes of the incubation period and amplitude were observed. Results Test mid- dose group has precede effect than test- L group and the test- H on the changes of the SEP incubation period and amplitude,but no obvious difference compared with control group. The test mid- dose group has the same effect with control group on the MEP incubation period,better than test high- dose group and test low- dose group. Test mid- dose group has precede effect than other groups on the MEP amplitude. Conclusion The mid- dose Jisuikang has the best curative effect for neural functional recovery after spinal cord injury.

关 键 词：脊髓康 脊髓损伤 体感诱发电位 运动诱发电位 

分 类 号：R285.5[医药卫生—中药学] R982[医药卫生—中医学]