《国家基本药物目录》(2012年版)中适宜儿童使用的化学药品和生物制品的分析  

Analysis on the chemical and biological products suitable for children in National Essential Medicine List (2012 edition)

作　　者：陈哲[1] 谢晓慧[1] 王晓玲[2] 郭春彦[2] 张艳菊[2] 胡泊洋[2] 王小川[1] 崔家玉[1] 

机构地区：[1]北京大学药学院,北京100191 [2]首都医科大学附属北京儿童医院药剂科,北京100145

出　　处：《中国临床药理学杂志》2015年第17期1786-1788,共3页The Chinese Journal of Clinical Pharmacology

基　　金：国家卫生计生委药政司<国家基本药物目录>(2012年版)适宜儿童药物品种;剂型;规格的研究基金资助项目

摘　　要：目的论证《国家基本药物目录》（2012年版）（以下简称2012版基药目录）中适宜儿童使用的化学药品和生物制品（以下简称化药）。方法依据化药最新版说明书、《中国国家处方集（化学药品与生物制品卷·儿童版）》、第4版《WHO儿童基本药物标准清单》以及文献和临床专家调研的结果,论证适宜儿童使用的活性成分和品种。提出适宜不同年龄段儿童的剂型,并据此筛选出相应的品种。通过计算,得出适宜不同年龄段儿童的规格。结果适宜儿童使用的化药有283种活性成分,占91.59%。适宜不同年龄段儿童的品种和规格占比：〈2岁分别为44.29%、28.14%;2~5岁分别为76.30%、50.06%;〉5岁分别为84.95%、80.60%。结论 2012版基药目录化药部分为儿童用药提供了重要保障,但适宜低龄儿童的剂型和规格仍存在较大缺失。Objective To demonstrate the chemical and biological products suitable for children in National Essential Medicine List（ 2012 Edition）（ NEML）. Methods The active ingredients and formulations suitable for children in NEML were demonstrated based on the latest version of instructions,‘Chinese National Formulary（ Chemicals and Biological Products for Children） ＇,the fourth edition ‘World Health Organization（ WHO） Model List of Essential Medicines for Children＇,the results of literature and the suggestions from clinic experts. List the dosage forms,formulations and strengths suitable for children of different ages.Results The amount of active ingredients suitable for children are 283,accounting for 91. 59%. The proportion of formulations and strengths suitable for children of different ages： less than 2 years old is 44. 29%and 28. 14% respectively,2- 5 years old is 76. 30% and 50. 06%respectively,more than 5 years old is 84. 95% and 80. 60% respectively. Conclusion Chemical and biological products in NEML provide important safeguard for children,but the dosage forms and strengths are not enough for young children.

关 键 词：基药目录 儿童 适宜性 活性成分 品种 剂型 规格 

分 类 号：R954[医药卫生—药学] R985