蛋白激酶C在心脏方面的研究进展  

Research progress of protein kinase C in the heart

作　　者：洪宏[1] 王红君 张荣[1] 

机构地区：[1]哈尔滨医科大学药学院药理学教研室,哈尔滨150086 [2]吉化集团公司总医院药剂科,吉林132022

出　　处：《中国临床药理学杂志》2015年第17期1789-1792,共4页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81102434,81470523)

摘　　要：蛋白激酶C(protein kinase C,PKC)是一个由不同基因编码的丝氨酸/苏氨酸蛋白激酶大家族,在人体各组织细胞中普遍存在,它对细胞信号的传导具有重要的调节作用。目前相关研究表明,对心脏产生保护作用的亚型主要涉及四种:PKCα、PKCβ2、PKCδ、PKCε。本文对PKC的信号传导以及PKC四种亚型在心脏疾病方面的研究现状做一综述。Protein kinase C（ PKC） is a serine / threonine encoded by different genes protein kinase family,widespread in every tissue cells in the human body,and they play an important role in the cell signal conduction. Heart disease is strived to be solved as the scientific problem of the academic circles all the time,it is a serious threat to human health. At present,related studies have shown that there are four clear isoforms in cardiac protection mainly including PKCα,PKCβ2,PKCδand PKCε. This article will review on the PKC signaling transduction and the research achievements about the heart disease.

关 键 词：蛋白激酶C 信号传导 心脏疾病 

分 类 号：R322.1[医药卫生—人体解剖和组织胚胎学]